Yan Li1, Chunxiao Han2, Jinghui Wang2, Wei Xiao3, Zhenzhong Wang3, Jingxiao Zhang2, Yinfeng Yang2, Shuwei Zhang2, Chunzhi Ai4. 1. Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Chemical Engineering, Dalian University of Technology, Dalian 116024, Liaoning, China. Electronic address: yanli@dlut.edu.cn. 2. Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Chemical Engineering, Dalian University of Technology, Dalian 116024, Liaoning, China. 3. State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Jiangsu Kanion Parmaceutical Co. Ltd., Lianyungang 222001, Jiangsu, China. 4. Lab of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Graduate School of the Chinese Academy of Sciences, Dalian 116023, Liaoning, China.
Abstract
ETHNOPHARMACOLOGY RELEVANCE: Though Traditional Chinese Medicine (TCM) has long been playing a significant role in the maintenance of health for people in Asia as well as many other places, the mechanism of its action still remains ambiguous for most of the plants used in TCM, such as Eucommia ulmoides Oliv., a kind of herb that is widely used to help regulate hypertension and the immune system nowadays. However, its functioning mechanism is still unknown. Thus it is necessary to exploit the mechanism of Eucommia ulmoides Oliv. METHODS: A systems pharmacology approach combining drug-likeness evaluation, oral bioavailability prediction, multiple drug targets prediction as well as network pharmacology techniques has been used. RESULTS: This comprehensive systematic approach helps successfully to identify 41 candidate compounds contained in Eucommia ulmoides Oliv. while 39 potential targets hit by these ingredients and helps to uncover the synergistic mechanism of action on a systematic level. CONCLUSIONS: Our work successfully explains the mechanism of the efficiency of Eucommia ulmoides Oliv. for the treatment of hypertension and enhancing immune. These results not only provide a new insight for the understanding of the chemical and pharmacological basis of Eucommia ulmoides Oliv., but also provide an efficient way for drug discovery from herbal medicine.
ETHNOPHARMACOLOGY RELEVANCE: Though Traditional Chinese Medicine (TCM) has long been playing a significant role in the maintenance of health for people in Asia as well as many other places, the mechanism of its action still remains ambiguous for most of the plants used in TCM, such as Eucommia ulmoides Oliv., a kind of herb that is widely used to help regulate hypertension and the immune system nowadays. However, its functioning mechanism is still unknown. Thus it is necessary to exploit the mechanism of Eucommia ulmoides Oliv. METHODS: A systems pharmacology approach combining drug-likeness evaluation, oral bioavailability prediction, multiple drug targets prediction as well as network pharmacology techniques has been used. RESULTS: This comprehensive systematic approach helps successfully to identify 41 candidate compounds contained in Eucommia ulmoides Oliv. while 39 potential targets hit by these ingredients and helps to uncover the synergistic mechanism of action on a systematic level. CONCLUSIONS: Our work successfully explains the mechanism of the efficiency of Eucommia ulmoides Oliv. for the treatment of hypertension and enhancing immune. These results not only provide a new insight for the understanding of the chemical and pharmacological basis of Eucommia ulmoides Oliv., but also provide an efficient way for drug discovery from herbal medicine.
Authors: Isabelle Risso-Gill; Dina Balabanova; Fadhlina Majid; Kien Keat Ng; Khalid Yusoff; Feisul Mustapha; Charlotte Kuhlbrandt; Robby Nieuwlaat; J-D Schwalm; Tara McCready; Koon K Teo; Salim Yusuf; Martin McKee Journal: BMC Health Serv Res Date: 2015-07-03 Impact factor: 2.655
Authors: Mingrui Hu; Yuanyuan Zhong; Wei Xiao; Yang Wang; Tao Tang; Shunshun Wang; Hanjin Cui; Teng Li; Jiekun Luo Journal: Evid Based Complement Alternat Med Date: 2021-08-06 Impact factor: 2.629