E Rodin1, T Constantino2, J Bigelow2. 1. Department of Neurology, University of Utah, Salt Lake City, UT, USA. Electronic address: e.rodin@utah.edu. 2. Intermountain Medical Center Neurosciences Institute, Murray, UT, USA.
Abstract
OBJECTIVE: To evaluate if interictal infraslow activity (ISA), as obtained from a conventional EEG system, can contribute information about the epileptogenic process. METHODS: The entire long-term intracranial monitoring sessions of 12 consecutive patients were evaluated on an XLTEK system for ISA. Three additional patients had long-term scalp recordings. RESULTS: In intracranial as well as scalp recordings, the ISA background was consistently higher in the waking state than during sleep. From this background emerged intermittently focal changes, which could achieve in intracranial recordings millivolt amplitudes, while they remained in the microvolt range in scalp recordings. Although they were mainly contiguous between adjacent channels, this was not necessarily the case and intermittent build-up could be seen distant from the epileptogenic zone or radiographic lesion. CONCLUSIONS: Interictal ISA can be detected in routine intracranial and scalp recordings, without the need for DC amplifiers, and can provide additional information. SIGNIFICANCE: Since ISA is a separate element of the electromagnetic spectrum, apparently non-neuronal in origin, its assessment should be included not only in the pre-surgical evaluation of epilepsy patients but also in patients with other neurologic disorders and normal volunteers.
OBJECTIVE: To evaluate if interictal infraslow activity (ISA), as obtained from a conventional EEG system, can contribute information about the epileptogenic process. METHODS: The entire long-term intracranial monitoring sessions of 12 consecutive patients were evaluated on an XLTEK system for ISA. Three additional patients had long-term scalp recordings. RESULTS: In intracranial as well as scalp recordings, the ISA background was consistently higher in the waking state than during sleep. From this background emerged intermittently focal changes, which could achieve in intracranial recordings millivolt amplitudes, while they remained in the microvolt range in scalp recordings. Although they were mainly contiguous between adjacent channels, this was not necessarily the case and intermittent build-up could be seen distant from the epileptogenic zone or radiographic lesion. CONCLUSIONS: Interictal ISA can be detected in routine intracranial and scalp recordings, without the need for DC amplifiers, and can provide additional information. SIGNIFICANCE: Since ISA is a separate element of the electromagnetic spectrum, apparently non-neuronal in origin, its assessment should be included not only in the pre-surgical evaluation of epilepsypatients but also in patients with other neurologic disorders and normal volunteers.
Authors: Pariya Salami; Noam Peled; Jessica K Nadalin; Louis-Emmanuel Martinet; Mark A Kramer; Jong W Lee; Sydney S Cash Journal: Clin Neurophysiol Date: 2020-05-29 Impact factor: 3.708