Julie Alperen1, Sean Brummel2, Katherine Tassiopoulos3, Claude A Mellins4, Deborah Kacanek2, Renee Smith5, George R Seage3, Anna-Barbara Moscicki6. 1. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Electronic address: jalperen@sdac.harvard.edu. 2. Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts. 3. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. 4. HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute and Columbia University, New York, New York. 5. Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois. 6. Department of Pediatrics, University of California-San Francisco, San Francisco, California.
Abstract
PURPOSE: This study examined risk factors associated with recent substance use (SU) among perinatally human immunodeficiency virus (HIV)-infected (PHIV+) and perinatally exposed, uninfected (PHEU) youth and compared SU lifetime prevalence with the general population of United States (U.S.) adolescents. METHODS: We conducted cross-sectional and longitudinal analyses of 511 PHIV+ and PHEU youth (mean age at study entry, 13.2 years; 51% female; 69% PHIV+; and 72% African-American) enrolled in a U.S. multisite prospective cohort study between 2007 and 2009. Substance use data were collected by audio computer-assisted self-interview. Youth Risk Behavior Surveillance System and Monitoring the Future data were used to compare SU lifetime prevalence with U.S. samples. RESULTS: Perinatal HIV infection was not a statistically significant risk factor for alcohol or marijuana use. Risk factors for alcohol use among PHIV+ youth included higher severity of emotional and conduct problems and alcohol and marijuana use in the home by the caregiver or others. Risk factors for marijuana use among PHIV+ youth included marijuana use in the home, higher severity of conduct problems, and stressful life events. Similar SU risk factors among PHEU youth included SU in the home and higher severity of conduct and emotional problems. Overall lifetime prevalence of SU by age was similar to that in national surveys. CONCLUSIONS: Although SU lifetime prevalence and risk factors for PHIV+ and PHEU adolescents were similar to national norms, the negative consequences are potentially greater for PHIV+ youth. Prevention efforts should begin before SU initiation and address the family and social environment and youth mental health status.
PURPOSE: This study examined risk factors associated with recent substance use (SU) among perinatally human immunodeficiency virus (HIV)-infected (PHIV+) and perinatally exposed, uninfected (PHEU) youth and compared SU lifetime prevalence with the general population of United States (U.S.) adolescents. METHODS: We conducted cross-sectional and longitudinal analyses of 511 PHIV+ and PHEU youth (mean age at study entry, 13.2 years; 51% female; 69% PHIV+; and 72% African-American) enrolled in a U.S. multisite prospective cohort study between 2007 and 2009. Substance use data were collected by audio computer-assisted self-interview. Youth Risk Behavior Surveillance System and Monitoring the Future data were used to compare SU lifetime prevalence with U.S. samples. RESULTS:Perinatal HIV infection was not a statistically significant risk factor for alcohol or marijuana use. Risk factors for alcohol use among PHIV+ youth included higher severity of emotional and conduct problems and alcohol and marijuana use in the home by the caregiver or others. Risk factors for marijuana use among PHIV+ youth included marijuana use in the home, higher severity of conduct problems, and stressful life events. Similar SU risk factors among PHEU youth included SU in the home and higher severity of conduct and emotional problems. Overall lifetime prevalence of SU by age was similar to that in national surveys. CONCLUSIONS: Although SU lifetime prevalence and risk factors for PHIV+ and PHEU adolescents were similar to national norms, the negative consequences are potentially greater for PHIV+ youth. Prevention efforts should begin before SU initiation and address the family and social environment and youth mental health status.
Authors: Ann Usitalo; Erin Leister; Katherine Tassiopoulos; Susannah Allison; Kathleen Malee; Mary E Paul; Renee Smith; Russell B Van Dyke; George R Seage; Claude A Mellins Journal: AIDS Care Date: 2013-06-26
Authors: Russell B Van Dyke; Sophia Lee; George M Johnson; Andrew Wiznia; Kathleen Mohan; Kenneth Stanley; Edward V Morse; Paul A Krogstad; Sharon Nachman Journal: Pediatrics Date: 2002-04 Impact factor: 7.124
Authors: Patricia E Lester; Robert E Weiss; Eric Rice; W Scott Comulada; Lynwood Lord; Susan Alber; Mary Jane Rotheram-Borus Journal: Am J Orthopsychiatry Date: 2009-01
Authors: Robert L Cook; Fang Zhu; Bea Herbeck Belnap; Kathleen Weber; Judith A Cook; David Vlahov; Tracey E Wilson; Nancy A Hessol; Michael Plankey; Andrea A Howard; Stephen R Cole; Gerald B Sharp; Jean L Richardson; Mardge H Cohen Journal: Am J Epidemiol Date: 2009-03-06 Impact factor: 4.897
Authors: C Paula Lewis-de Los Angeles; Paige L Williams; Yanling Huo; Shirlene D Wang; Kristina A Uban; Megan M Herting; Kathleen Malee; Ram Yogev; John G Csernansky; Sharon Nichols; Russell B Van Dyke; Elizabeth R Sowell; Lei Wang Journal: Brain Behav Immun Date: 2017-01-10 Impact factor: 7.217
Authors: Anna-Barbara Moscicki; Sepideh Farhat; Tzy-Jyun Yao; Mark I Ryder; Jonathan S Russell; Russell B Van Dyke; Rohan Hazra; Caroline H Shiboski Journal: Sex Transm Dis Date: 2016-08 Impact factor: 2.830
Authors: Caroline H Shiboski; Tzy-Jyun Yao; Jonathan S Russell; Mark I Ryder; Russell B Van Dyke; George R Seage; Anna-Barbara Moscicki Journal: AIDS Date: 2018-11-13 Impact factor: 4.177
Authors: Katrina D Hermetet-Lindsay; Katharine F Correia; Paige L Williams; Renee Smith; Kathleen M Malee; Claude A Mellins; Richard M Rutstein Journal: AIDS Behav Date: 2017-09
Authors: C Paula Lewis-de Los Angeles; Kathryn I Alpert; Paige L Williams; Kathleen Malee; Yanling Huo; John G Csernansky; Ram Yogev; Russell B Van Dyke; Elizabeth R Sowell; Lei Wang Journal: J Pediatric Infect Dis Soc Date: 2016-12 Impact factor: 3.164
Authors: Lynnette L Harris; Miriam C Chernoff; Sharon L Nichols; Paige L Williams; Patricia A Garvie; Cenk Yildirim; Stephen R McCauley; Steven Paul Woods Journal: Child Neuropsychol Date: 2017-08-07 Impact factor: 2.500
Authors: M Isabel Fernández; Heather C Huszti; Patrick A Wilson; Shoshana Kahana; Sharon Nichols; René Gonin; Jiahong Xu; Bill G Kapogiannis Journal: AIDS Behav Date: 2015-05
Authors: Kristi E Gamarel; Larry Brown; Christopher W Kahler; M Isabel Fernandez; Douglas Bruce; Sharon Nichols Journal: Drug Alcohol Depend Date: 2016-10-11 Impact factor: 4.492