| Literature DB >> 24239175 |
Sun-Young Ko1, Chan-Jeoung Park2, Sang-Hyuk Park3, Young-Uk Cho3, Seongsoo Jang3, Eul-Ju Seo3, Nayoung Kim4, Dae-Young Kim5, Kyung Nam Koh6, Ho Joon Im6, Jong-Jin Seo6, Hyun-Sook Chi3.
Abstract
Data regarding the prognostic significance of CXCR4 and VLA-4 in ALL are limited. Especially, VLA-4 has not been evaluated at the time of diagnosis in both adult and childhood ALL patients. We prospectively analyzed the expression of VLA-4 and CXCR4 in 54 patients (VLA-4 in 29 adults and 25 children and CXCR4 in 22 adults and 24 children) newly diagnosed with ALL by flow cytometry. Expression levels of VLA-4 and CXCR4 were not different between adults and children with ALL. High CXCR4 and low VLA-4 expression each correlated with worse prognosis in adults; patients with high CXCR4 expression had shorter disease-free survival (p=0.01) and overall survival (p=0.04) and patients with low VLA-4 expression had shorter disease-free survival (p=0.02). Expression levels of CXCR4 and VLA-4 did not predict patient prognosis in children. Analysis of CXCR4 and VLA-4 expression at diagnosis in adults with ALL can provide useful information on patient prognosis.Entities:
Keywords: Acute lymphoblastic leukemia; Adult; CXCR4; Prognostic marker; Survival; VLA-4
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Year: 2013 PMID： 24239175 DOI： 10.1016/j.leukres.2013.10.016
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156