Emily Vogtmann1, Yong-Bing Xiang2, Hong-Lan Li2, Quiyin Cai3, Qi-Jun Wu2, Li Xie2, Guo-Liang Li3, Gong Yang3, John W Waterbor4, Emily B Levitan4, Bin Zhang5, Wei Zheng3, Xiao-Ou Shu6. 1. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States; Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China; State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China; Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States. 2. Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China; State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China. 3. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States. 4. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, United States. 5. Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, OH, United States. 6. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States. Electronic address: Xiao-Ou.Shu@Vanderbilt.edu.
Abstract
PURPOSE: To assess the associations between cruciferous vegetable (CV) intake, GST gene polymorphisms, and colorectal cancer (CRC) in a population of Chinese men. METHODS: Using incidence density sampling, CRC cases (N = 340) diagnosed before December 31, 2010 within the Shanghai Men's Health Study were matched to noncases (N = 673). CV intake was assessed from a food frequency questionnaire and by isothiocyanate levels from spot urine samples. GSTM1 and GSTT1 were categorized as null (0 copies) versus non-null (1 or 2 copies). Conditional logistic regression was used to calculate odds ratios and 95% confidence intervals for the association between CV intake and GST gene variants with CRC, and statistical interactions were evaluated. RESULTS: CRC risk was not associated with CV intake, whether measured by self-report or by urinary isothiocyanate nor with GST gene variants. No statistical interactions were detected between CV intake and GST gene variants on the odds of CRC. Stratifying by timing of urine sample collection and excluding CRC cases diagnosed in the first 2 years did not materially alter the results. CONCLUSIONS: This study provides no evidence supporting the involvement of CV intake in the development of CRC in Chinese men.
PURPOSE: To assess the associations between cruciferous vegetable (CV) intake, GST gene polymorphisms, and colorectal cancer (CRC) in a population of Chinesemen. METHODS: Using incidence density sampling, CRC cases (N = 340) diagnosed before December 31, 2010 within the Shanghai Men's Health Study were matched to noncases (N = 673). CV intake was assessed from a food frequency questionnaire and by isothiocyanate levels from spot urine samples. GSTM1 and GSTT1 were categorized as null (0 copies) versus non-null (1 or 2 copies). Conditional logistic regression was used to calculate odds ratios and 95% confidence intervals for the association between CV intake and GST gene variants with CRC, and statistical interactions were evaluated. RESULTS: CRC risk was not associated with CV intake, whether measured by self-report or by urinary isothiocyanate nor with GST gene variants. No statistical interactions were detected between CV intake and GST gene variants on the odds of CRC. Stratifying by timing of urine sample collection and excluding CRC cases diagnosed in the first 2 years did not materially alter the results. CONCLUSIONS: This study provides no evidence supporting the involvement of CV intake in the development of CRC in Chinesemen.
Authors: Faye Turner; Gillian Smith; Christoph Sachse; Tracy Lightfoot; R Colin Garner; C Roland Wolf; David Forman; D Timothy Bishop; Jennifer H Barrett Journal: Int J Cancer Date: 2004-11-01 Impact factor: 7.396
Authors: D W West; M L Slattery; L M Robison; K L Schuman; M H Ford; A W Mahoney; J L Lyon; A W Sorensen Journal: Am J Epidemiol Date: 1989-11 Impact factor: 4.897
Authors: Junlong Jack Chi; Hongchun Li; Zhuan Zhou; Javier Izquierdo-Ferrer; Yifan Xue; Cindy M Wavelet; Gary E Schiltz; Bin Zhang; Massimo Cristofanilli; Xinghua Lu; Ivet Bahar; Yong Wan Journal: EBioMedicine Date: 2019-10-25 Impact factor: 8.143