Annabelle Bédard1, Raphaëlle Varraso2, Margaux Sanchez2, Françoise Clavel-Chapelon3, Jan-Paul Zock4, Francine Kauffmann2, Nicole Le Moual2. 1. Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, F-94807 Villejuif, France; Univ Paris Sud, UMRS 1018, F-94807 Villejuif, France. Electronic address: annabelle.bedard@inserm.fr. 2. Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, F-94807 Villejuif, France; Univ Paris Sud, UMRS 1018, F-94807 Villejuif, France. 3. Univ Paris Sud, UMRS 1018, F-94807 Villejuif, France; Inserm, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, hormones et santé de la femme Team, Gustave Roussy Institute, F-94805 Villejuif, France. 4. Centre for Research in Environmental Epidemiology (CREAL), 08003 Barcelona, Spain; IMIM, Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), 08003 Spain.
Abstract
OBJECTIVE: There is increasing evidence on the deleterious role in asthma of the use of household cleaning products in spray forms in adults. Household help might induce misclassification errors. The aim of the present analysis was to study associations between household exposure to cleaning sprays and current asthma in elderly women, taking into account household help. METHODS: A nested case-control survey on respiratory health was undertaken among a random sample of French women from the E3N study. Data were available for 570 women (235 with current asthma and 335 without asthma history; 68 years old on average, 59% never smokers). Three estimates of domestic exposure were used: 1) self-reported, 2) using principal component analysis, 3) a composite score for sprays. Associations between domestic exposures and asthma were assessed by logistic regression, adjusted for age, educational level, BMI and smoking status. Analyses were further stratified on household help in order to evaluate a potential misclassification bias. RESULTS: Among women without household help (n = 325), a significant association was observed between weekly use of at least one spray and current asthma (OR [95% CI]: 1.86[1.04-3.33]). No association was observed among women with household help. CONCLUSIONS: Weekly household use of cleaning sprays may have a deleterious effect on asthma. It is important to take into account household help to limit misclassification bias.
OBJECTIVE: There is increasing evidence on the deleterious role in asthma of the use of household cleaning products in spray forms in adults. Household help might induce misclassification errors. The aim of the present analysis was to study associations between household exposure to cleaning sprays and current asthma in elderly women, taking into account household help. METHODS: A nested case-control survey on respiratory health was undertaken among a random sample of French women from the E3N study. Data were available for 570 women (235 with current asthma and 335 without asthma history; 68 years old on average, 59% never smokers). Three estimates of domestic exposure were used: 1) self-reported, 2) using principal component analysis, 3) a composite score for sprays. Associations between domestic exposures and asthma were assessed by logistic regression, adjusted for age, educational level, BMI and smoking status. Analyses were further stratified on household help in order to evaluate a potential misclassification bias. RESULTS: Among women without household help (n = 325), a significant association was observed between weekly use of at least one spray and current asthma (OR [95% CI]: 1.86[1.04-3.33]). No association was observed among women with household help. CONCLUSIONS: Weekly household use of cleaning sprays may have a deleterious effect on asthma. It is important to take into account household help to limit misclassification bias.
Authors: Orianne Dumas; Aleta S Wiley; Paul K Henneberger; Frank E Speizer; Jan-Paul Zock; Raphaëlle Varraso; Nicole Le Moual; Krislyn M Boggs; Carlos A Camargo Journal: Am J Ind Med Date: 2016-11-15 Impact factor: 2.214
Authors: Pierre Lemire; Sofia Temam; Sarah Lyon-Caen; Catherine Quinot; Etienne Sévin; Sophie Remacle; Karine Supernant; Rémy Slama; Orianne Dumas; Valérie Siroux; Nicole Le Moual; The Sepages Study Group Journal: Int J Environ Res Public Health Date: 2021-03-24 Impact factor: 3.390