Jing Du1, Yu Liang, Feng Xu, Bing Sun, Zhao Wang. 1. Department of Pharmacology, School of Medicine, Tsinghua University, Beijing, China; Institute of Biomechanics and Medical Engineering, School of Aerospace, Tsinghua University, Beijing, China.
Abstract
OBJECTIVE: Alzheimer's Disease (AD) is well characterized by the accumulated Aβ plaque in hippocampus and cerebral cortex concomitant with markedly reduced study and learning ability. Trehalose, a natural disaccharide, has been shown to have neural protective properties and exhibited therapeutic effects in animal models of several neural degenerative disorders. However, the effect of trehalose on AD pathology remains largely unknown. METHODS: In this study, we evaluated the effects of trehalose in APP/PS1 transgenic mice through behaviour tests and biochemical analyses. KEY FINDINGS: We found that the impaired cognitive and learning ability was improved and Aβ deposit in hippocampus was reduced. CONCLUSIONS: These results suggested that trehalose could be a potential therapeutic drug for the treatment of AD.
OBJECTIVE:Alzheimer's Disease (AD) is well characterized by the accumulated Aβ plaque in hippocampus and cerebral cortex concomitant with markedly reduced study and learning ability. Trehalose, a natural disaccharide, has been shown to have neural protective properties and exhibited therapeutic effects in animal models of several neural degenerative disorders. However, the effect of trehalose on AD pathology remains largely unknown. METHODS: In this study, we evaluated the effects of trehalose in APP/PS1transgenic mice through behaviour tests and biochemical analyses. KEY FINDINGS: We found that the impaired cognitive and learning ability was improved and Aβ deposit in hippocampus was reduced. CONCLUSIONS: These results suggested that trehalose could be a potential therapeutic drug for the treatment of AD.
Authors: Barry Boland; Wai Haung Yu; Olga Corti; Bertrand Mollereau; Alexandre Henriques; Erwan Bezard; Greg M Pastores; David C Rubinsztein; Ralph A Nixon; Michael R Duchen; Giovanna R Mallucci; Guido Kroemer; Beth Levine; Eeva-Liisa Eskelinen; Fanny Mochel; Michael Spedding; Caroline Louis; Olivier R Martin; Mark J Millan Journal: Nat Rev Drug Discov Date: 2018-08-17 Impact factor: 84.694
Authors: Mara K O'Neill; Brent F Piligian; Claire D Olson; Peter J Woodruff; Benjamin M Swarts Journal: Pure Appl Chem Date: 2017-01-11 Impact factor: 2.453