Literature DB >> 24236747

Flow cytometric identification of 76 patients with biclonal disease among 5523 patients with chronic lymphocytic leukaemia (B-CLL) and its genetic characterization.

Wolfgang Kern1, Ulrike Bacher, Susanne Schnittger, Frank Dicker, Tamara Alpermann, Torsten Haferlach, Claudia Haferlach.   

Abstract

Multiparameter flow cytometry (MFC) identifies rare cases of biclonal disease in chronic lymphocytic leukaemia (CLL). By MFC, we identified 76 patients with biclonal disease in a cohort of 5523 CLL patients (1·4%). Fluorescence in situ hybridization and chromosome banding analysis revealed five and six cases, respectively, with two different cytogenetic aberrations due to clonal evolution. Two different B-cell receptor rearrangements and IGHV subtypes were more frequent in biclonal than in monoclonal CLL by MFC (37·1% vs. 2·7%; P < 0·001). Patients with biclonal CLL by MFC showed a trend to a shorter time to treatment than monoclonal CLL (P = 0·080).
© 2013 John Wiley & Sons Ltd.

Entities:  

Keywords:  Biclonal chronic lymphocytic leukaemia; IGHV mutation analysis; chromosome banding analysis; interphase fluorescence in situ hybridization; multiparameter flow cytometry

Mesh：

Year:  2013        PMID： 24236747     DOI： 10.1111/bjh.12652

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  6 in total

1.  Immunoglobulin transcript sequence and somatic hypermutation computation from unselected RNA-seq reads in chronic lymphocytic leukemia.

Authors:  James S Blachly; Amy S Ruppert; Weiqiang Zhao; Susan Long; Joseph Flynn; Ian Flinn; Jeffrey Jones; Kami Maddocks; Leslie Andritsos; Emanuela M Ghia; Laura Z Rassenti; Thomas J Kipps; Albert de la Chapelle; John C Byrd
Journal:  Proc Natl Acad Sci U S A       Date:  2015-03-18       Impact factor: 11.205

2.  Consistency of the Moreau CLL score.

Authors:  Marc Sorigue; Edurne Sarrate; Mireia Franch-Sarto; Evarist Feliu; Jordi Junca
Journal:  J Clin Lab Anal       Date:  2017-12-28       Impact factor: 2.352

3.  Single-Cell Analysis and Next-Generation Immuno-Sequencing Show That Multiple Clones Persist in Patients with Chronic Lymphocytic Leukemia.

Authors:  Jitra Kriangkum; Sarah N Motz; Tanner Mack; Sara Beiggi; Eva Baigorri; Hemalatha Kuppusamy; Andrew R Belch; James B Johnston; Linda M Pilarski
Journal:  PLoS One       Date:  2015-09-09       Impact factor: 3.240

4.  High Viral Loads of Epstein-Barr Virus DNA in Peripheral Blood of Patients with Chronic Lymphocytic Leukemia Associated with Unfavorable Prognosis.

Authors:  Ewelina Grywalska; Jacek Roliński; Marcin Pasiarski; Izabela Korona-Glowniak; Maciej Maj; Agata Surdacka; Agnieszka Grafka; Agnieszka Stelmach-Gołdyś; Michał Zgurski; Stanisław Góźdź; Anna Malm; Piotr Grabarczyk; Elżbieta Starosławska
Journal:  PLoS One       Date:  2015-10-13       Impact factor: 3.240

5.  Low-count monoclonal B-cell lymphocytosis persists after seven years of follow up and is associated with a poorer outcome.

Authors:  Ignacio Criado; Arancha Rodríguez-Caballero; M Laura Gutiérrez; Carlos E Pedreira; Miguel Alcoceba; Wendy Nieto; Cristina Teodosio; Paloma Bárcena; Alfonso Romero; Paulino Fernández-Navarro; Marcos González; Julia Almeida; Alberto Orfao
Journal:  Haematologica       Date:  2018-03-22       Impact factor: 9.941

6.  Double IGHV DNA gene rearrangements in CLL: influence of mixed-mutated and -unmutated rearrangements on outcomes in CLL.

Authors:  B Heyman; A D Volkheimer; J B Weinberg
Journal:  Blood Cancer J       Date:  2016-07-01       Impact factor: 11.037
  6 in total

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