Literature DB >> 2423512

One of the antigenic determinants of paired helical filaments is related to tau protein.

N Nukina, Y Ihara.   

Abstract

Paired helical filaments (PHF) are unusual neuronal fibers which accumulate progressively in the brain in Alzheimer's disease (AD). The insolubility of PHF in various kinds of solvents enabled us to obtain highly purified PHF, but prevented the application of conventional analytical methods to identify their components. Here we report that antibodies against purified PHF recognize tau protein, a brain-specific microtubule-associated protein, suggesting that a portion of PHF is tau protein.

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Year:  1986        PMID： 2423512     DOI： 10.1093/oxfordjournals.jbchem.a135625

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


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