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Literature DB >> 24234821

New fluorescent labels for time-resolved detection of biomolecules.

M Sauer¹, K T Han, R Müller, A Schulz, R Tadday, S Seeger, J Wolfrum, J Arden-Jacob, G Deltau, N J Marx, K H Drexhage.

Abstract

New dyes with characteristic fluorescence lifetimes have been developed for bioanalytical applications. Based upon the concept of "multiplex dyes," we have designed rhodamine dyes with nearly identical absorption and emission spectral characteristics but different fluorescence lifetimes. Extending this principle to applications with laser diodes, new rhodamines with functional groups for covalent coupling of analytes have been developed. The new labels exhibit absortion and fluorescence beyond 600 nm and have a high quantum efficiency, even in aqueous buffer systems.

Entities: Chemical

Year: 1993 PMID： 24234821 DOI： 10.1007/BF00862730

Source DB: PubMed Journal: J Fluoresc ISSN： 1053-0509 Impact factor: 2.217

5 in total

1. High-speed DNA sequencing by capillary gel electrophoresis.

Authors: L M Smith
Journal: Nature Date: 1991-02-28 Impact factor: 49.962

2. Three DNA sequencing methods using capillary gel electrophoresis and laser-induced fluorescence.

Authors: H Swerdlow; J Z Zhang; D Y Chen; H R Harke; R Grey; S L Wu; N J Dovichi; C Fuller
Journal: Anal Chem Date: 1991-12-15 Impact factor: 6.986

3. A system for rapid DNA sequencing with fluorescent chain-terminating dideoxynucleotides.

Authors: J M Prober; G L Trainor; R J Dam; F W Hobbs; C W Robertson; R J Zagursky; A J Cocuzza; M A Jensen; K Baumeister
Journal: Science Date: 1987-10-16 Impact factor: 47.728

4. Automated DNA sequencing: ultrasensitive detection of fluorescent bands during electrophoresis.

Authors: W Ansorge; B Sproat; J Stegemann; C Schwager; M Zenke
Journal: Nucleic Acids Res Date: 1987-06-11 Impact factor: 16.971

5. Fluorescent rhodol derivatives: versatile, photostable labels and tracers.

Authors: J E Whitaker; R P Haugland; D Ryan; P C Hewitt; R P Haugland; F G Prendergast
Journal: Anal Biochem Date: 1992-12 Impact factor: 3.365

5 in total

4 in total

New fluorescent labels for time-resolved detection of biomolecules.

1. High-speed DNA sequencing by capillary gel electrophoresis.

2. Three DNA sequencing methods using capillary gel electrophoresis and laser-induced fluorescence.

3. A system for rapid DNA sequencing with fluorescent chain-terminating dideoxynucleotides.

4. Automated DNA sequencing: ultrasensitive detection of fluorescent bands during electrophoresis.

5. Fluorescent rhodol derivatives: versatile, photostable labels and tracers.

1. Acridones and quinacridones: novel fluorophores for fluorescence lifetime studies.

2. New fluorescent dyes in the red region for biodiagnostics.

3. Multiplexed gold nanorod array biochip for multi-sample analysis.

4. Diazaoxatriangulenium: synthesis of reactive derivatives and conjugation to bovine serum albumin.