Literature DB >> 24234682

The impact of hypoxia in hepatocellular carcinoma metastasis.

Carmen Chak-Lui Wong1, Alan Ka-Lun Kai, Irene Oi-Lin Ng.   

Abstract

Hypoxia is a common phenomenon in hepatocellular carcinoma (HCC). Hypoxia stabilizes transcription factor, hypoxia-inducible factor (HIF), to activate gene transcription. Expression of HIF is closely associated with metastasis and poor prognosis in HCC. HIF mediates expression of genes that are involved in every step of HCC metastasis including epithelial-mesenchymal transition, invasion of the extracellular matrix, intravasation, extravasation, and secondary growth of the metastases. Because HIF is the central regulator of HCC metastasis, HIF inhibitors are attractive tools when used alone or as combined treatment to curb HCC metastasis. This review will summarize the current findings on the impact of hypoxia/HIF in HCC, with a particular focus on cancer metastasis.

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Year:  2013        PMID： 24234682     DOI： 10.1007/s11684-013-0301-3

Source DB:  PubMed          Journal:  Front Med        ISSN： 2095-0217            Impact factor:   4.592


  50 in total

1.  Overexpression of matrix metalloproteinase 9 gene in hepatocellular carcinoma with invasive potential.

Authors:  S Arii; M Mise; T Harada; M Furutani; S Ishigami; M Niwano; M Mizumoto; M Fukumoto; M Imamura
Journal:  Hepatology       Date:  1996-08       Impact factor: 17.425

Review 2.  Matrix metalloproteinases and tumor metastasis.

Authors:  Elena I Deryugina; James P Quigley
Journal:  Cancer Metastasis Rev       Date:  2006-03       Impact factor: 9.264

3.  Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas.

Authors:  H Higashitsuji; K Itoh; T Nagao; S Dawson; K Nonoguchi; T Kido; R J Mayer; S Arii; J Fujita
Journal:  Nat Med       Date:  2000-01       Impact factor: 53.440

Review 4.  HIF-1 and HIF-2 transcription factors--similar but not identical.

Authors:  Agnieszka Loboda; Alicja Jozkowicz; Jozef Dulak
Journal:  Mol Cells       Date:  2010-04-12       Impact factor: 5.034

5.  LOX-mediated collagen crosslinking is responsible for fibrosis-enhanced metastasis.

Authors:  Thomas R Cox; Demelza Bird; Ann-Marie Baker; Holly E Barker; Melisa W-Y Ho; Georgina Lang; Janine T Erler
Journal:  Cancer Res       Date:  2013-01-23       Impact factor: 12.701

6.  Antisense hypoxia-inducible factor-1alpha augments transcatheter arterial embolization in the treatment of hepatocellular carcinomas in rats.

Authors:  Xueying Sun; Hongchi Jiang; Xian Jiang; Hongtao Tan; Qinghui Meng; Bei Sun; Ruian Xu; Geoffrey W Krissansen
Journal:  Hum Gene Ther       Date:  2009-04       Impact factor: 5.695

7.  Why cancer at the primary site and in the lymph nodes contributes to the risk of cancer death.

Authors:  James S Michaelson; L Leon Chen; Melvin J Silverstein; Justin A Cheongsiatmoy; Martin C Mihm; Arthur J Sober; Kenneth K Tanabe; Barbara L Smith; Jerry Younger
Journal:  Cancer       Date:  2009-11-01       Impact factor: 6.860

Review 8.  Detection and characterization of tumor hypoxia using pO2 histography.

Authors:  Peter Vaupel; Michael Höckel; Arnulf Mayer
Journal:  Antioxid Redox Signal       Date:  2007-08       Impact factor: 8.401

9.  p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways.

Authors:  Jing Fu; Yao Chen; Jie Cao; Tao Luo; You-Wen Qian; Wen Yang; Yi-Bin Ren; Bo Su; Guang-Wen Cao; Yuan Yang; Yi-Qun Yan; Feng Shen; Meng-Chao Wu; Gen-Sheng Feng; Hong-Yang Wang
Journal:  Hepatology       Date:  2010-12-10       Impact factor: 17.298

10.  HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.

Authors:  H Zhang; C C L Wong; H Wei; D M Gilkes; P Korangath; P Chaturvedi; L Schito; J Chen; B Krishnamachary; P T Winnard; V Raman; L Zhen; W A Mitzner; S Sukumar; G L Semenza
Journal:  Oncogene       Date:  2011-08-22       Impact factor: 9.867
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  29 in total

1.  Translational and transcriptional responses in human primary hepatocytes under hypoxia.

Authors:  Gaya K Hettiarachchi; Upendra K Katneni; Ryan C Hunt; Jacob M Kames; John C Athey; Haim Bar; Zuben E Sauna; Joseph R McGill; Juan C Ibla; Chava Kimchi-Sarfaty
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2019-03-28       Impact factor: 4.052

2.  Targeting hypoxia-inducible factor-2α enhances sorafenib antitumor activity via β-catenin/C-Myc-dependent pathways in hepatocellular carcinoma.

Authors:  Feng Liu; Xiaofeng Dong; Hong Lv; Peng Xiu; Tao Li; Fuhai Wang; Zongzhen Xu; Jie Li
Journal:  Oncol Lett       Date:  2015-06-03       Impact factor: 2.967

3.  Defective Beclin-1 and elevated hypoxia-inducible factor (HIF)-1α expression are closely linked to tumorigenesis, differentiation, and progression of hepatocellular carcinoma.

Authors:  Nisreen A A Osman; Dalia M Abd El-Rehim; Inas M Kamal
Journal:  Tumour Biol       Date:  2015-01-17

Review 4.  Hypoxia-inducible factors and innate immunity in liver cancer.

Authors:  Vincent Wai-Hin Yuen; Carmen Chak-Lui Wong
Journal:  J Clin Invest       Date:  2020-10-01       Impact factor: 14.808

5.  Hypoxia-inducible MiR-182 promotes angiogenesis by targeting RASA1 in hepatocellular carcinoma.

Authors:  Chengli Du; Xiaoyu Weng; Wendi Hu; Zhen Lv; Heng Xiao; Chaofeng Ding; Owusu-Anash K Gyabaah; Haiyang Xie; Lin Zhou; Jian Wu; Shusen Zheng
Journal:  J Exp Clin Cancer Res       Date:  2015-06-28

6.  De novo synthesis of C4.4A in hepatocellular carcinoma promotes migration and invasion of tumor cells.

Authors:  Magdalena Görtz; Uwe Galli; Thomas Longerich; Margot Zöller; Ulrike Erb; Peter Schemmer
Journal:  Oncol Rep       Date:  2017-09-20       Impact factor: 3.906

7.  Expression of a urokinase-type plasminogen activator during tumor growth leads to angiogenesis via galanin activation in tumor-bearing mice.

Authors:  Hiroyuki Yamamoto; Rina Okada; Rika Tanaka; Keiko Unno; Kazuaki Iguchi
Journal:  FEBS Open Bio       Date:  2017-10-09       Impact factor: 2.693

8.  Use of Ultrasmall Superparamagnetic Iron Oxide Enhanced Susceptibility Weighted Imaging and Mean Vessel Density Imaging to Monitor Antiangiogenic Effects of Sorafenib on Experimental Hepatocellular Carcinoma.

Authors:  Shuohui Yang; Jiang Lin; Fang Lu; Zhihong Han; Caixia Fu; Hongchen Gu
Journal:  Contrast Media Mol Imaging       Date:  2017-06-21       Impact factor: 3.161

Review 9.  The Crosstalk between Hypoxia and Innate Immunity in the Development of Obesity-Related Nonalcoholic Fatty Liver Disease.

Authors:  María Teresa Arias-Loste; Emilio Fábrega; Marcos López-Hoyos; Javier Crespo
Journal:  Biomed Res Int       Date:  2015-09-28       Impact factor: 3.411

10.  microRNA-526b servers as a prognostic factor and exhibits tumor suppressive property by targeting Sirtuin 7 in hepatocellular carcinoma.

Authors:  Xin Liu; Liu Yang; Jianfeng Tu; Wenwei Cai; Meiqi Zhang; Zhangxuan Shou; Yingmin Yao; Qiuran Xu
Journal:  Oncotarget       Date:  2017-09-23
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