Uptake, distribution and immunotoxicological effects of mercury in mice.

The uptake and distribution of mercury in various organs and tissues of mice were examined after administration with mercuric chloride (HgCl2) or mercuric sulphide (HgS). The results show that mice treated with HgCl2 were found to have significantly higher levels of mercury in various organs and tissues as compared to HgS-treated animals. Except for the kidneys, no significant differences were found in mercury levels between the HgS-treated and control mice. This appears to be due to the higher solubility of HgCl2, allowing for its greater absorption into the body. Irrespective of the mercurial administered, the kidneys contained the highest concentration of mercury, followed by the liver and brain. Mercury was also found to confer protection against Trypanosoma evansi, possibly due to its toxicity. When treated with HgS, enhanced antibody production and increased levels of circulating leucocytes was seen. HgCl2 and HgS-treated mice showed no signs of anorexia, no significant changes being found in growth and food intake.