Literature DB >> 2423372

Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides.

J M Gutteridge.   

Abstract

Hydrogen peroxide and organic hydroperoxides react with haemoglobin to release iron which can be complexed to apotransferrin, bleomycin and desferrioxamine. This released iron promotes deoxyribose degradation by a Fenton reaction, DNA degradation in the presence of bleomycin and stimulates lipid peroxidation. It is likely that iron released from haemoglobin is the true generator of hydroxyl radicals in the Fenton reaction.

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Year:  1986        PMID： 2423372     DOI： 10.1016/0014-5793(86)80626-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  86 in total

1.  Effects of oxyradicals on oxymyoglobin. Deoxygenation, haem removal and iron release.

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Review 2.  Drug derived radicals: mediators of the side effects of anti-inflammatory drugs?

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3.  Protecting peroxidase activity of multilayer enzyme-polyion films using outer catalase layers.

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Journal:  J Phys Chem B       Date:  2007-12-05       Impact factor: 2.991

4.  Oxidative modification by low levels of HOOH can transform myoglobin to an oxidase.

Authors:  Y Osawa; K Korzekwa
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-15       Impact factor: 11.205

Review 5.  Modulation of oxidative stress as an anticancer strategy.

Authors:  Chiara Gorrini; Isaac S Harris; Tak W Mak
Journal:  Nat Rev Drug Discov       Date:  2013-12       Impact factor: 84.694

6.  Transition metals in legume root nodules: iron-dependent free radical production increases during nodule senescence.

Authors:  M Becana; R V Klucas
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

7.  Oxidative stress in subarachnoid haemorrhage: significance in acute brain injury and vasospasm.

Authors:  R E Ayer; J H Zhang
Journal:  Acta Neurochir Suppl       Date:  2008

8.  Increase in bleomycin-detectable iron in ischaemia/reperfusion injury to rat kidneys.

Authors:  R Baliga; N Ueda; S V Shah
Journal:  Biochem J       Date:  1993-05-01       Impact factor: 3.857

9.  Up-regulation of heme oxygenase-1 in rat spleen after aniline exposure.

Authors:  Jianling Wang; Huaxian Ma; Paul J Boor; V M Sadagopa Ramanujam; G A S Ansari; M Firoze Khan
Journal:  Free Radic Biol Med       Date:  2009-12-04       Impact factor: 7.376

Review 10.  Metals and lipid oxidation. Contemporary issues.

Authors:  K M Schaich
Journal:  Lipids       Date:  1992-03       Impact factor: 1.880
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