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Literature DB >> 2423371

Pig kidney Na+,K+-ATPase. Primary structure and spatial organization.

N N Modyanov, N E Broude, K E Petrukhin, A V Grishin, N M Arzamazova, N A Aldanova, G S Monastyrskaya, E D Sverdlov.

Abstract

cDNAs complementary to pig kidney mRNAs coding for alpha- and beta-subunits of Na+,K+-ATPase were cloned and sequenced. Selective tryptic hydrolysis of the alpha-subunit within the membrane-bound enzyme and tryptic hydrolysis of the immobilized isolated beta-subunit were also performed. The mature alpha- and beta-subunits contain 1016 and 302 amino acid residues, respectively. Structural data on the peptides from extramembrane regions of the alpha-subunit and on glycopeptides of the beta-subunit underlie a model for the transmembrane arrangement of Na+,K+-ATPase polypeptide chains.

Entities: Chemical Gene Species

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Year: 1986 PMID： 2423371 DOI： 10.1016/0014-5793(86)80616-0

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

24 in total

1. Definition of surface-exposed and trans-membranous regions of the (Ca(2+)-Mg2+)-ATPase of sarcoplasmic reticulum using anti-peptide antibodies.

Authors: A M Mata; I Matthews; R E Tunwell; R P Sharma; A G Lee; J M East
Journal: Biochem J Date: 1992-09-01 Impact factor: 3.857

2. Chemical modification of Glu-953 of the alpha chain of Na+,K(+)-ATPase associated with inactivation of cation occlusion.

Authors: R Goldshleger; D M Tal; J Moorman; W D Stein; S J Karlish
Journal: Proc Natl Acad Sci U S A Date: 1992-08-01 Impact factor: 11.205

Review 3. The genes of Na,K-ATPase, a selfreview.

Authors: E D Sverdlov
Journal: Genetica Date: 1991 Impact factor: 1.082

4. The 60- to 90-kDa parietal cell autoantigen associated with autoimmune gastritis is a beta subunit of the gastric H+/K(+)-ATPase (proton pump).

Authors: B H Toh; P A Gleeson; R J Simpson; R L Moritz; J M Callaghan; I Goldkorn; C M Jones; T M Martinelli; F T Mu; D C Humphris
Journal: Proc Natl Acad Sci U S A Date: 1990-08 Impact factor: 11.205

10. Role of the Na,K-ATPase beta-subunit in the cellular accumulation and maturation of the enzyme as assessed by glycosylation inhibitors.

Authors: D Zamofing; B C Rossier; K Geering
Journal: J Membr Biol Date: 1988-08 Impact factor: 1.843

Pig kidney Na+,K+-ATPase. Primary structure and spatial organization.

1. Definition of surface-exposed and trans-membranous regions of the (Ca(2+)-Mg2+)-ATPase of sarcoplasmic reticulum using anti-peptide antibodies.

2. Chemical modification of Glu-953 of the alpha chain of Na+,K(+)-ATPase associated with inactivation of cation occlusion.

Review 3. The genes of Na,K-ATPase, a selfreview.

4. The 60- to 90-kDa parietal cell autoantigen associated with autoimmune gastritis is a beta subunit of the gastric H+/K(+)-ATPase (proton pump).

Review 5. Subunit assembly and functional maturation of Na,K-ATPase.

6. Ouabain-resistant mutants of the rat Na,K-ATPase alpha 2 isoform identified by using an episomal expression vector.

7. Location of signal sequences for membrane insertion of the Na+,K+-ATPase alpha subunit.

8. Multiple genes encode the human Na+,K+-ATPase catalytic subunit.

Review 9. Structural basis for E1-E2 conformational transitions in Na,K-pump and Ca-pump proteins.

10. Role of the Na,K-ATPase beta-subunit in the cellular accumulation and maturation of the enzyme as assessed by glycosylation inhibitors.