Literature DB >> 2423325

Location of 'continuous' antigenic determinants in the protruding regions of proteins.

J M Thornton, M S Edwards, W R Taylor, D J Barlow.   

Abstract

A simple method is described to locate 'antigenic' peptides from the alpha-carbon co-ordinates of a protein, based on protrusion from the protein's globular surface. A good correlation is found between those parts of a protein which protrude and the experimentally determined antigenic peptides in myoglobin, lysozyme and myohemerythrin. A comparison is made between the use of protrusion index, mobility, solvent accessibility and hydrophilicity for predicting the most likely antigenic peptides.

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Year:  1986        PMID： 2423325      PMCID： PMC1166746          DOI： 10.1002/j.1460-2075.1986.tb04226.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  19 in total

Review 1.  The atomic mobility component of protein antigenicity.

Authors:  J A Tainer; E D Getzoff; Y Paterson; A J Olson; R A Lerner
Journal:  Annu Rev Immunol       Date:  1985       Impact factor: 28.527

2.  Immunochemical studies of tobacco mosaic virus--III. Demonstration of five antigenic regions in the protein sub-unit.

Authors:  R C De L Milton; M H van Regenmortel
Journal:  Mol Immunol       Date:  1979-03       Impact factor: 4.407

3.  The effect of a single amino acid substitution on the antigenic specificity of the loop region of lysozyme.

Authors:  I M Ibrahimi; J Eder; E M Prager; A C Wilson; R Arnon
Journal:  Mol Immunol       Date:  1980-01       Impact factor: 4.407

4.  Prediction of protein antigenic determinants from amino acid sequences.

Authors:  T P Hopp; K R Woods
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

5.  An X-ray study of the physiological-temperature form of hen egg-white lysozyme at 2 A resolution.

Authors:  J Berthou; A Lifchitz; P Artymiuk; P Jollès
Journal:  Proc R Soc Lond B Biol Sci       Date:  1983-03-22

6.  The interpretation of protein structures: estimation of static accessibility.

Authors:  B Lee; F M Richards
Journal:  J Mol Biol       Date:  1971-02-14       Impact factor: 5.469

7.  Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features.

Authors:  W Kabsch; C Sander
Journal:  Biopolymers       Date:  1983-12       Impact factor: 2.505

8.  How antigenic are antigenic peptides?

Authors:  S J Leach
Journal:  Biopolymers       Date:  1983-01       Impact factor: 2.505

9.  Antibodies with specificities to preselected protein regions evoked by free synthetic peptides representing protein antigenic sites or other surface locations: demonstration with myoglobin.

Authors:  D R Young; H E Schmitz; M Z Atassi
Journal:  Mol Immunol       Date:  1983-05       Impact factor: 4.407

10.  Amino and carboxy-terminal regions in globular proteins.

Authors:  J M Thornton; B L Sibanda
Journal:  J Mol Biol       Date:  1983-06-25       Impact factor: 5.469
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  69 in total

1.  Characterization of the Arabidopsis lecRK-a genes: members of a superfamily encoding putative receptors with an extracellular domain homologous to legume lectins.

Authors:  C Hervé; J Serres; P Dabos; H Canut; A Barre; P Rougé; B Lescure
Journal:  Plant Mol Biol       Date:  1999-03       Impact factor: 4.076

2.  Predicting interaction sites from the energetics of isolated proteins: a new approach to epitope mapping.

Authors:  Guido Scarabelli; Giulia Morra; Giorgio Colombo
Journal:  Biophys J       Date:  2010-05-19       Impact factor: 4.033

3.  Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.

Authors:  Lujia Zhou; Lucia Chávez-Gutiérrez; Katrijn Bockstael; Ragna Sannerud; Wim Annaert; Patrick C May; Eric Karran; Bart De Strooper
Journal:  J Biol Chem       Date:  2011-01-05       Impact factor: 5.157

4.  High-throughput prediction of protein antigenicity using protein microarray data.

Authors:  Christophe N Magnan; Michael Zeller; Matthew A Kayala; Adam Vigil; Arlo Randall; Philip L Felgner; Pierre Baldi
Journal:  Bioinformatics       Date:  2010-10-07       Impact factor: 6.937

5.  Correlation between antigenicity and variability in the vls antigenic variation system of Borrelia burgdorferi.

Authors:  Wei Zhou; Dustin Brisson
Journal:  Microbes Infect       Date:  2017-01-10       Impact factor: 2.700

6.  Prediction of residues in discontinuous B-cell epitopes using protein 3D structures.

Authors:  Pernille Haste Andersen; Morten Nielsen; Ole Lund
Journal:  Protein Sci       Date:  2006-09-25       Impact factor: 6.725

7.  Peptide antisera as sequence-specific probes of protein conformational transitions: calmodulin exhibits calcium-dependent changes in antigenicity.

Authors:  J Gariépy; T A Mietzner; G K Schoolnik
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

8.  Proteomics in Vaccinology and Immunobiology: An Informatics Perspective of the Immunone.

Authors:  Irini A. Doytchinova; Paul Taylor; Darren R. Flower
Journal:  J Biomed Biotechnol       Date:  2003

9.  Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies.

Authors:  Hongying Duan; Xuejun Chen; Jeffrey C Boyington; Cheng Cheng; Yi Zhang; Alexander J Jafari; Tyler Stephens; Yaroslav Tsybovsky; Oleksandr Kalyuzhniy; Peng Zhao; Sergey Menis; Martha C Nason; Erica Normandin; Maryam Mukhamedova; Brandon J DeKosky; Lance Wells; William R Schief; Ming Tian; Frederick W Alt; Peter D Kwong; John R Mascola
Journal:  Immunity       Date:  2018-07-31       Impact factor: 31.745

10.  Humanization of murine monoclonal antibodies through variable domain resurfacing.

Authors:  M A Roguska; J T Pedersen; C A Keddy; A H Henry; S J Searle; J M Lambert; V S Goldmacher; W A Blättler; A R Rees; B C Guild
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205
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