Literature DB >> 24233095

Detection and identification ofPodophyllotoxin produced by cell cultures derived from podophyllum hexandrum royle.

W van Uden1, N Pras, J F Visser, T M Malingré.   

Abstract

The phenylpropanoid derived lignan podophyllotoxin, occurring inPodophyllum species, is used as a starting compound for the chemical synthesis of the antitumour agents etoposide (VP-16-213) and teniposide (VM-26). At present, the availability of this lignan becomes increasingly limited. As an alternative source, cell cultures originating fromPodophyllum hexandrum Royle were initiated. Analysis of the cell extracts using different HPLC systems as well as TLC, indicated the presence of podophyllotoxin. After prepurification of the extracts by means of ITLC, the identity was confirmed by mass spectrometric analysis. Dark-grown cultures accumulated considerable higher amounts of podophyllotoxin in comparison with the light-grown cultures.

Entities:  

Year:  1989        PMID： 24233095     DOI： 10.1007/BF00716832

Source DB:  PubMed          Journal:  Plant Cell Rep        ISSN： 0721-7714            Impact factor:   4.570


  7 in total

1.  On the podophyllotoxins of root cultures of Linum flavum.

Authors:  J Berlin; N Bedorf; C Mollenschott; V Wray; F Sasse; G Höfle
Journal:  Planta Med       Date:  1988-06       Impact factor: 3.352

2.  The biological activities of podophyllotoxin compounds.

Authors:  Y Inamori; M Kubo; H Tsujibo; M Ogawa; K Baba; M Kozawa; E Fujita
Journal:  Chem Pharm Bull (Tokyo)       Date:  1986-09       Impact factor: 1.645

3.  Formation of beta-peltatin-A methyl ether and coniferin by root cultures of Linum flavum.

Authors:  J Berlin; V Wray; C Mollenschott; F Sasse
Journal:  J Nat Prod       Date:  1986 May-Jun       Impact factor: 4.050

4.  Nutrient requirements of suspension cultures of soybean root cells.

Authors:  O L Gamborg; R A Miller; K Ojima
Journal:  Exp Cell Res       Date:  1968-04       Impact factor: 3.905

5.  Formation of podophyllotoxins by Podophyllum peltatum tissue cultures.

Authors:  P G Kadkade
Journal:  Naturwissenschaften       Date:  1981-09

6.  Effects of VM26 (teniposide), a specific inhibitor of type II DNA topoisomerase, on SV40 DNA replication in vivo.

Authors:  A Richter; U Strausfeld; R Knippers
Journal:  Nucleic Acids Res       Date:  1987-04-24       Impact factor: 16.971

Review 7.  Etoposide and teniposide. Bioanalysis, metabolism and clinical pharmacokinetics.

Authors:  J J Holthuis
Journal:  Pharm Weekbl Sci       Date:  1988-06-17
  7 in total
  10 in total

1.  Expressed sequence tags and molecular cloning and characterization of gene encoding pinoresinol/lariciresinol reductase from Podophyllum hexandrum.

Authors:  Dhammaprakash Pandhari Wankhede; Dipul Kumar Biswas; Subramani Rajkumar; Alok Krishna Sinha
Journal:  Protoplasma       Date:  2013-05-08       Impact factor: 3.356

2.  An efficient in vitro system for somatic embryogenesis and podophyllotoxin production in Podophyllum hexandrum Royle.

Authors:  Manoharan Rajesh; Ganeshan Sivanandhan; Murugaraj Jeyaraj; Rajan Chackravarthy; Markandan Manickavasagam; N Selvaraj; Andy Ganapathi
Journal:  Protoplasma       Date:  2014-03-16       Impact factor: 3.356

3.  Transcriptome-wide identification and characterization of CAD isoforms specific for podophyllotoxin biosynthesis from Podophyllum hexandrum.

Authors:  Dipto Bhattacharyya; Saptarshi Hazra; Anindyajit Banerjee; Riddhi Datta; Deepak Kumar; Saikat Chakrabarti; Sharmila Chattopadhyay
Journal:  Plant Mol Biol       Date:  2016-07-07       Impact factor: 4.076

4.  Establishment of hairy root cultures of Linum flavum producing the lignan 5-methoxypodophyllotoxin.

Authors:  A Oostdam; J N Mol; L H van der Plas
Journal:  Plant Cell Rep       Date:  1993-05       Impact factor: 4.570

5.  Production of tumour-inhibitory lignans in callus cultures of Podophyllum hexandrum.

Authors:  A G Heyenga; J A Lucas; P M Dewick
Journal:  Plant Cell Rep       Date:  1990-11       Impact factor: 4.570

6.  The accumulation of podophyllotoxin-β-D-glucoside by cell suspension cultures derived from the conifer Callitris drummondii.

Authors:  W van Uden; N Pras; T M Maingré
Journal:  Plant Cell Rep       Date:  1990-09       Impact factor: 4.570

7.  Increased podophyllotoxin production in Podophyllum hexandrum cell suspension cultures after feeding coniferyl alcohol as a β-cyclodextrin complex.

Authors:  H J Woerdenbag; W van Uden; H W Frijlink; C F Lerk; N Pras; T M Malingré
Journal:  Plant Cell Rep       Date:  1990-07       Impact factor: 4.570

8.  Production of podophyllotoxin from Podophyllum hexandrum: a potential natural product for clinically useful anticancer drugs.

Authors:  A Giri; M Lakshmi Narasu
Journal:  Cytotechnology       Date:  2000-10       Impact factor: 2.058

9.  Proteins differentially expressed in elicited cell suspension culture of Podophyllum hexandrum with enhanced podophyllotoxin content.

Authors:  Dipto Bhattacharyya; Ragini Sinha; Srijani Ghanta; Amrita Chakraborty; Saptarshi Hazra; Sharmila Chattopadhyay
Journal:  Proteome Sci       Date:  2012-05-23       Impact factor: 2.480

10.  Methyl Jasmonate Regulates Podophyllotoxin Accumulation in Podophyllum hexandrum by Altering the ROS-Responsive Podophyllotoxin Pathway Gene Expression Additionally through the Down Regulation of Few Interfering miRNAs.

Authors:  Saptarshi Hazra; Dipto Bhattacharyya; Sharmila Chattopadhyay
Journal:  Front Plant Sci       Date:  2017-02-14       Impact factor: 5.753
  10 in total

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