Literature DB >> 24232184

Complex diseases require complex therapies.

Ravi Iyengar1.   

Abstract

Mesh：

Year:  2013        PMID： 24232184      PMCID： PMC3981088          DOI： 10.1038/embor.2013.177

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


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  10 in total

Review 1.  Signaling networks: the origins of cellular multitasking.

Authors:  J D Jordan; E M Landau; R Iyengar
Journal:  Cell       Date:  2000-10-13       Impact factor: 41.582

2.  T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia.

Authors:  Michael Kalos; Bruce L Levine; David L Porter; Sharyn Katz; Stephan A Grupp; Adam Bagg; Carl H June
Journal:  Sci Transl Med       Date:  2011-08-10       Impact factor: 17.956

Review 3.  Toward predictive models of mammalian cells.

Authors:  Avi Ma'ayan; Robert D Blitzer; Ravi Iyengar
Journal:  Annu Rev Biophys Biomol Struct       Date:  2005

4.  Pipeline for COPD drugs flows with combination candidates.

Authors:  Helen Thompson
Journal:  Nat Med       Date:  2013-09       Impact factor: 53.440

5.  Emergent properties of networks of biological signaling pathways.

Authors:  U S Bhalla; R Iyengar
Journal:  Science       Date:  1999-01-15       Impact factor: 47.728

Review 6.  Interactome networks and human disease.

Authors:  Marc Vidal; Michael E Cusick; Albert-László Barabási
Journal:  Cell       Date:  2011-03-18       Impact factor: 41.582

7.  Detecting drug interactions from adverse-event reports: interaction between paroxetine and pravastatin increases blood glucose levels.

Authors:  N P Tatonetti; J C Denny; S N Murphy; G H Fernald; G Krishnan; V Castro; P Yue; P S Tsao; P S Tsau; I Kohane; D M Roden; R B Altman
Journal:  Clin Pharmacol Ther       Date:  2011-05-25       Impact factor: 6.875

8.  Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop.

Authors:  Yunlei Yang; Deniz Atasoy; Helen H Su; Scott M Sternson
Journal:  Cell       Date:  2011-09-16       Impact factor: 41.582

9.  A positive feedback signal transduction loop determines timing of cerebellar long-term depression.

Authors:  Keiko Tanaka; George J Augustine
Journal:  Neuron       Date:  2008-08-28       Impact factor: 17.173

10.  Systems pharmacology of adverse event mitigation by drug combinations.

Authors:  Shan Zhao; Tomohiro Nishimura; Yibang Chen; Evren U Azeloglu; Omri Gottesman; Chiara Giannarelli; Mohammad U Zafar; Ludovic Benard; Juan J Badimon; Roger J Hajjar; Joseph Goldfarb; Ravi Iyengar
Journal:  Sci Transl Med       Date:  2013-10-09       Impact factor: 17.956
  10 in total
  13 in total

Review 1.  Systems Pharmacology Links GPCRs with Retinal Degenerative Disorders.

Authors:  Yu Chen; Krzysztof Palczewski
Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-03-23       Impact factor: 13.820

2.  Modeling cytokine regulatory network dynamics driving neuroinflammation in central nervous system disorders.

Authors:  Warren D Anderson; Rajanikanth Vadigepalli
Journal:  Drug Discov Today Dis Models       Date:  2017-04-10

Review 3.  The IBD interactome: an integrated view of aetiology, pathogenesis and therapy.

Authors:  Heitor S P de Souza; Claudio Fiocchi; Dimitrios Iliopoulos
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2017-08-23       Impact factor: 46.802

4.  Eyes on systems pharmacology.

Authors:  Yu Chen; Timothy S Kern; Philip D Kiser; Krzysztof Palczewski
Journal:  Pharmacol Res       Date:  2016-10-05       Impact factor: 7.658

Review 5.  Salvia miltiorrhiza in Breast Cancer Treatment: A Review of Its Phytochemistry, Derivatives, Nanoparticles, and Potential Mechanisms.

Authors:  Huan Zhao; Bing Han; Xuan Li; Chengtao Sun; Yufei Zhai; Man Li; Mi Jiang; Weiping Zhang; Yi Liang; Guoyin Kai
Journal:  Front Pharmacol       Date:  2022-05-05       Impact factor: 5.988

6.  Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration.

Authors:  Yu Chen; Grazyna Palczewska; Ikuo Masuho; Songqi Gao; Hui Jin; Zhiqian Dong; Linn Gieser; Matthew J Brooks; Philip D Kiser; Timothy S Kern; Kirill A Martemyanov; Anand Swaroop; Krzysztof Palczewski
Journal:  Sci Signal       Date:  2016-07-26       Impact factor: 8.192

7.  Human aging and disease: Lessons from age-related macular degeneration.

Authors:  Jennings Luu; Krzysztof Palczewski
Journal:  Proc Natl Acad Sci U S A       Date:  2018-02-26       Impact factor: 11.205

8.  Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case.

Authors:  Farshid S Garmaroudi; Diane E Handy; Yang-Yu Liu; Joseph Loscalzo
Journal:  PLoS Comput Biol       Date:  2016-03-17       Impact factor: 4.475

9.  A data-driven modeling approach to identify disease-specific multi-organ networks driving physiological dysregulation.

Authors:  Warren D Anderson; Danielle DeCicco; James S Schwaber; Rajanikanth Vadigepalli
Journal:  PLoS Comput Biol       Date:  2017-07-21       Impact factor: 4.475

10.  Inflammatory Bowel Disease: Complexity and Variability Need Integration.

Authors:  Claudio Fiocchi
Journal:  Front Med (Lausanne)       Date:  2018-03-21
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