BACKGROUND: Little is known about the determining factors related to the administration of continuous palliative sedation. Knowledge of these determinants may assist physicians in identifying patients who are at high risk of developing refractory symptoms, enable physicians to inform patients, and optimize close monitoring. OBJECTIVE: The aim of this systematic review was to identify determinants of the administration of continuous palliative sedation. DESIGN: A systematic review of PubMed, EMBASE, and CINAHL was performed to identify English, Dutch, and German language papers published from January 1990 through April 2011. Inclusion was based on the following criteria: patient-based research on continuous palliative sedation, studies investigating determinants of palliative sedation and/or comparison between sedated and nonsedated cohorts, and studies using multivariate analyses and of fair to good or good methodological quality. RESULTS: In total, eight papers were reviewed. The following nine factors were found to be associated with the administration of continuous palliative sedation: younger age, male sex, having cancer, feelings of hopelessness, dying in a hospital, living in a Dutch speaking community setting, very nonreligious or extremely nonreligious physicians, physicians working in "other hospital" specialties, and physicians in favor of assisted death. CONCLUSIONS: Given the variation in study designs and the limitations of the included studies, the outcomes should be interpreted carefully. Further research is needed, particularly regarding factors that can be influenced and that may alter the course of a patient's symptoms and the patient's eventual need for palliative sedation.
BACKGROUND: Little is known about the determining factors related to the administration of continuous palliative sedation. Knowledge of these determinants may assist physicians in identifying patients who are at high risk of developing refractory symptoms, enable physicians to inform patients, and optimize close monitoring. OBJECTIVE: The aim of this systematic review was to identify determinants of the administration of continuous palliative sedation. DESIGN: A systematic review of PubMed, EMBASE, and CINAHL was performed to identify English, Dutch, and German language papers published from January 1990 through April 2011. Inclusion was based on the following criteria: patient-based research on continuous palliative sedation, studies investigating determinants of palliative sedation and/or comparison between sedated and nonsedated cohorts, and studies using multivariate analyses and of fair to good or good methodological quality. RESULTS: In total, eight papers were reviewed. The following nine factors were found to be associated with the administration of continuous palliative sedation: younger age, male sex, having cancer, feelings of hopelessness, dying in a hospital, living in a Dutch speaking community setting, very nonreligious or extremely nonreligious physicians, physicians working in "other hospital" specialties, and physicians in favor of assisted death. CONCLUSIONS: Given the variation in study designs and the limitations of the included studies, the outcomes should be interpreted carefully. Further research is needed, particularly regarding factors that can be influenced and that may alter the course of a patient's symptoms and the patient's eventual need for palliative sedation.
Authors: Sarah Ziegler; Margareta Schmid; Matthias Bopp; Georg Bosshard; Milo Alan Puhan Journal: J Gen Intern Med Date: 2018-03-20 Impact factor: 5.128
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Authors: Xavier Busquet-Duran; Eduard Moreno-Gabriel; Eva Maria Jiménez-Zafra; Magda Tura-Poma; Olga Bosch-DelaRosa; Anna Moragas-Roca; Susana Martin-Moreno; Emilio Martínez-Losada; Silvia Crespo-Ramírez; Lola Lestón-Lado; Núria Salamero-Tura; Joana Llobera-Estrany; Ariadna Salvago-Leiracha; Ana Isabel López-García; Josep María Manresa-Domínguez; Teresa Morandi-Garde; Eda Sara Persentili-Viure; Pere Torán-Monserrat Journal: Int J Environ Res Public Health Date: 2021-11-23 Impact factor: 3.390
Authors: Sandra Kurkowski; Maria Heckel; Larissa Pfaller; Joachim Peters; Jeremias Bazata; Eva Schildmann; Christoph Ostgathe Journal: BMC Palliat Care Date: 2022-05-13 Impact factor: 3.113