Literature DB >> 24226822

Production of canthin-6-one alkaloids by cell suspension cultures of Brucea javanica (L.) Merr.

K C Liu1, S L Yang, M F Roberts, J D Phillipson.   

Abstract

Cell suspension cultures of Brucea javanica (L.) Merr. were used to determine culture growth characteristics and production of canthin-6-one alkaloids. The major alkaloids produced were canthin-6-one, 11-hydroxycanthin-6-one, 5-methoxycanthin-6-one and 11-methoxycanthin-6-one. Alkaloids were synthesised throughout the 36 day growth cycle of the cells with maximum amounts within the cells occurring between days 20 to 28; approximately 10% of the alkaloids were in the medium at day 24 rising to 45% at day 32.

Entities:  

Year:  1990        PMID： 24226822     DOI： 10.1007/BF00232297

Source DB:  PubMed          Journal:  Plant Cell Rep        ISSN： 0721-7714            Impact factor:   4.570


  10 in total

1.  Plants as Sources of Antimalarial Drugs Part. 1. In vitro Test Method for the Evaluation of Crude Extracts from Plants.

Authors:  M J O'neill; D H Bray; P Boardman; J D Phillipson; D C Warhurst
Journal:  Planta Med       Date:  1985-10       Impact factor: 3.352

2.  Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids.

Authors:  C W Wright; M J O'Neill; J D Phillipson; D C Warhurst
Journal:  Antimicrob Agents Chemother       Date:  1988-11       Impact factor: 5.191

3.  Plants as sources of antimalarial drugs, Part 4: Activity of Brucea javanica fruits against chloroquine-resistant Plasmodium falciparum in vitro and against Plasmodium berghei in vivo.

Authors:  M J O'Neill; D H Bray; P Boardman; K L Chan; J D Phillipson; D C Warhurst; W Peters
Journal:  J Nat Prod       Date:  1987 Jan-Feb       Impact factor: 4.050

4.  Antitumor agents: LXXXVII. Cytotoxic antileukemic canthin-6-one alkaloids from Brucea antidysenterica and the structure activity relationships of their related derivatives.

Authors:  N Fukamiya; M Okano; T Aratani; K Negoro; Y M Lin; K H Lee
Journal:  Planta Med       Date:  1987-04       Impact factor: 3.352

5.  Plants as sources of antimalarial drugs: in vitro antimalarial activities of some quassinoids.

Authors:  M J O'Neill; D H Bray; P Boardman; J D Phillipson; D C Warhurst; W Peters; M Suffness
Journal:  Antimicrob Agents Chemother       Date:  1986-07       Impact factor: 5.191

6.  In vitro amoebicidal testing of natural products; Part I. Methodology.

Authors:  A T Keene; A Harris; J D Phillipson; D C Warhurst
Journal:  Planta Med       Date:  1986-08       Impact factor: 3.352

7.  Production of cytotoxic canthin-6-one alkaloids by Ailanthus altissima plant cell cultures.

Authors:  L A Anderson; A Harris; J D Phillipson
Journal:  J Nat Prod       Date:  1983 May-Jun       Impact factor: 4.050

8.  Plant anticancer agents. XXIV. Alkaloid constituents of Simaba multiflora.

Authors:  M Arisawa; A D Kinghorn; G A Cordell; N R Farnsworth
Journal:  J Nat Prod       Date:  1983 Mar-Apr       Impact factor: 4.050

9.  Studies on Ailanthus altissima cell suspension cultures : Precursor feeding of L-[methylene-(14)C]tryptophan and L-tryptophan.

Authors:  L A Anderson; C A Hay; M F Roberts; J D Phillipson
Journal:  Plant Cell Rep       Date:  1986-10       Impact factor: 4.570

10.  Cytotoxic Quassinoids from Odyendyea gabonensis Stem Bark: Isolation and High-Field NMR.

Authors:  P G Waterman; S A Ampofo
Journal:  Planta Med       Date:  1984-06       Impact factor: 3.352
  10 in total
  1 in total

1.  In vitro production of alkaloids: Factors, approaches, challenges and prospects.

Authors:  Sayeed Ahmad; Madhukar Garg; Ennus Tajuddin Tamboli; M Z Abdin; S H Ansari
Journal:  Pharmacogn Rev       Date:  2013-01
  1 in total

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