Literature DB >> 24226392

Matrix design for matrix-assisted laser desorption ionization: Sensitive determination of PAH-DNA adducts.

M George1, J M Wellemans, R L Cerny, M L Gross, K Li, E L Cavalieri.   

Abstract

Two matrices, 4-phenyl-α-eyanocinnamic acid (PCC) and 4-benzyloxy-α-eyanocinnamic acid (BCC), were identified for the determination of polycyclic aromatic hydrocarbon (PAH) adducts of DNA bases by matrix-assisted laser desorption ionization. These matrices were designed based on the concept that the matrix and the analyte should have structural similarities. PCC is a good matrix for the desorption of not only PAH-modified DNA bases, but also PAHs themselves and their metabolites. Detections can be made at the femtomolar level.

Entities:  

Year:  1994        PMID： 24226392     DOI： 10.1016/1044-0305(94)80021-9

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN： 1044-0305            Impact factor:   3.109


  12 in total

1.  Structural characterization of polycyclic aromatic hydrocarbon dihydrodiol epoxide DNA adducts using matrix-assisted laser desorption/ionization Fourier transform mass spectrometry.

Authors:  E A Stemmler; M V Buchanan; G B Hurst; R L Hettich
Journal:  Anal Chem       Date:  1994-04-15       Impact factor: 6.986

2.  Protein ladder sequencing.

Authors:  B T Chait; R Wang; R C Beavis; S B Kent
Journal:  Science       Date:  1993-10-01       Impact factor: 47.728

3.  Synthesis and structure determination of the adducts formed by electrochemical oxidation of the potent carcinogen dibenzo[a,I]pyrene in the presence of nucleosides.

Authors:  N V RamaKrishna; N S Padmavathi; E L Cavalieri; E G Rogan; R L Cerny; M L Gross
Journal:  Chem Res Toxicol       Date:  1993 Jul-Aug       Impact factor: 3.739

4.  Time-of-flight mass spectrometry of underivatized single-stranded DNA oligomers by matrix-assisted laser desorption.

Authors:  K J Wu; T A Shaler; C H Becker
Journal:  Anal Chem       Date:  1994-05-15       Impact factor: 6.986

5.  Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of chemically modified oligonucleotides.

Authors:  B H Wang; K Biemann
Journal:  Anal Chem       Date:  1994-06-01       Impact factor: 6.986

6.  Mechanism of aralkyl-DNA adduct formation from benzo[a]pyrene in vivo.

Authors:  K H Stansbury; J W Flesher; R C Gupta
Journal:  Chem Res Toxicol       Date:  1994 Mar-Apr       Impact factor: 3.739

7.  Binding of benzo[a]pyrene to DNA by cytochrome P-450 catalyzed one-electron oxidation in rat liver microsomes and nuclei.

Authors:  E L Cavalieri; E G Rogan; P D Devanesan; P Cremonesi; R L Cerny; M L Gross; W J Bodell
Journal:  Biochemistry       Date:  1990-05-22       Impact factor: 3.162

8.  Matrix-assisted laser desorption ionization mass spectrometry with 2-(4-hydroxyphenylazo)benzoic acid matrix.

Authors:  P Juhasz; C E Costello; K Biemann
Journal:  J Am Soc Mass Spectrom       Date:  1993-05       Impact factor: 3.109

Review 9.  Tandem mass spectrometry for the determination of deoxyribonucleic acid damage by polycyclic aromatic hydrocarbons. Plenary lecture.

Authors:  J Wellemans; R L Cerny; M L Gross
Journal:  Analyst       Date:  1994-04       Impact factor: 4.616

10.  Structural Characterization of Normal and Modified Oligonucleotides by Matrix-assisted Laser Desorption Fourier Transform Mass Spectrometry.

Authors:  R Hettich; M Buchanan
Journal:  J Am Soc Mass Spectrom       Date:  1991-09       Impact factor: 3.109
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  3 in total

1.  Matrix-assisted laser desorption/ionization mass spectrometry methods for oligodeoxynucleotides: improvements in matrix, detection limits, quantification, and sequencing.

Authors:  L K Zhang; M L Gross
Journal:  J Am Soc Mass Spectrom       Date:  2000-10       Impact factor: 3.109

2.  Characterization of labeled oligonucleotides using enzymatic digestion and tandem mass spectrometry.

Authors:  H Wu; R L Morgan; H Aboleneen
Journal:  J Am Soc Mass Spectrom       Date:  1998-07       Impact factor: 3.109

3.  Product ion studies of diastereomeric benzo[ghi]fluoranthene tetraols by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and post-source decay.

Authors:  D M Huffer; H F Chang; B P Cho; L K Zhang; M P Chiarelli
Journal:  J Am Soc Mass Spectrom       Date:  2001-04       Impact factor: 3.262
  3 in total

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