Literature DB >> 2422635

Effects of somatostatin and a somatostatin agonist on diet-induced pancreatitis in mice.

H Degertekin, A Ertan, K Akdamar, R Yates, I Chen, D H Coy, A Arimura.   

Abstract

We examined the effects of somatostatin-14 and the potent somatostatin agonist (N-acetyl-[Des(Ala1,Gly2),p-Cl-Phe6,D-Trp8]-somatostatin amide) on choline deficient, ethionine enriched diet (CDED)-induced acute pancreatitis in mice. Serum amylase determinations were performed, and specimens from the pancreas were examined by light and electron microscopy. No significant beneficial effects of somatostatin or its agonist were found in this model of acute pancreatitis.

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Year:  1985        PMID: 2422635     DOI: 10.1016/0196-9781(85)90457-7

Source DB:  PubMed          Journal:  Peptides        ISSN: 0196-9781            Impact factor:   3.750


  6 in total

1.  Effects of somatostatin on acute pancreatitis induced in rats by injection of taurocholate and trypsin into a temporarily closed duodenal loop.

Authors:  P De Rai; C Franciosi; G M Confalonieri; R Biffi; B Andreoni; F Uggeri; A Malesci
Journal:  Int J Pancreatol       Date:  1988-07

Review 2.  Clinical uses of gut peptides.

Authors:  J Geoghegan; T N Pappas
Journal:  Ann Surg       Date:  1997-02       Impact factor: 12.969

3.  Effects of somatostatin on acute canine experimental pancreatitis.

Authors:  D E Schlarman; M C Beinfeld; C Andrus; D L Kaminski
Journal:  Int J Pancreatol       Date:  1987-08

4.  A randomised, double blind, multicentre trial of octreotide in moderate to severe acute pancreatitis.

Authors:  W Uhl; M W Büchler; P Malfertheiner; H G Beger; G Adler; W Gaus
Journal:  Gut       Date:  1999-07       Impact factor: 23.059

5.  Octreotide ameliorates glucose intolerance following acute experimental pancreatitis.

Authors:  B Avni; R Haddad; H Kashtan; D Kaplan; E Graf; A Siegal; Y Skornick; O Kaplan
Journal:  Dig Dis Sci       Date:  1998-01       Impact factor: 3.199

6.  Effect of somatostatin 14 on pure human pancreatic secretion.

Authors:  L Gullo; P Priori; C Scarpignato; F Baldoni; G Mattioli; L Barbara
Journal:  Dig Dis Sci       Date:  1987-10       Impact factor: 3.199

  6 in total

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