Literature DB >> 24224611

2-Pyridonate titanium complexes for chemoselectivity. Accessing intramolecular hydroaminoalkylation over hydroamination.

Eugene Chong1, Laurel L Schafer.   

Abstract

Chemoselectivity of intramolecular hydroaminoalkylation over hydroamination has been achieved with a bis(3-phenyl-2-pyridonate) titanium complex. Primary aminoalkenes are selectively α-alkylated by C-H functionalization adjacent to nitrogen to access five- and six-membered cycloalkylamines with a good substrate-dependent diastereoselectivity of up to 19:1.

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Year:  2013        PMID： 24224611     DOI： 10.1021/ol402890m

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Antitrypanosomatid Pharmacomodulation at Position 3 of the 8-Nitroquinolin-2(1H)-one Scaffold Using Palladium-Catalysed Cross-Coupling Reactions.

Authors:  Julien Pedron; Clotilde Boudot; Sandra Bourgeade-Delmas; Alix Sournia-Saquet; Lucie Paloque; Maryam Rastegari; Mansour Abdoulaye; Hussein El-Kashef; Colin Bonduelle; Geneviève Pratviel; Susan Wyllie; Alan H Fairlamb; Bertrand Courtioux; Pierre Verhaeghe; Alexis Valentin
Journal:  ChemMedChem       Date:  2018-09-17       Impact factor: 3.466

2.  Scandium-catalysed intermolecular hydroaminoalkylation of olefins with aliphatic tertiary amines.

Authors:  Adi E Nako; Juzo Oyamada; Masayoshi Nishiura; Zhaomin Hou
Journal:  Chem Sci       Date:  2016-07-04       Impact factor: 9.825

3.  Differences between the elimination of early and late transition metals: DFT mechanistic insights into the titanium-catalyzed synthesis of pyrroles from alkynes and diazenes.

Authors:  Jiandong Guo; Xi Deng; Chunyu Song; Yu Lu; Shuanglin Qu; Yanfeng Dang; Zhi-Xiang Wang
Journal:  Chem Sci       Date:  2016-12-22       Impact factor: 9.825

4.  Photocatalytic α-Tertiary Amine Synthesis via C-H Alkylation of Unmasked Primary Amines.

Authors:  Alison S H Ryder; William B Cunningham; George Ballantyne; Tom Mules; Anna G Kinsella; Jacob Turner-Dore; Catherine M Alder; Lee J Edwards; Blandine S J McKay; Matthew N Grayson; Alexander J Cresswell
Journal:  Angew Chem Int Ed Engl       Date:  2020-06-11       Impact factor: 16.823
  4 in total

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