Literature DB >> 24223583

ROS-mediated regulation of CXCR4 in cancer.

Mahandranauth A Chetram1, Cimona V Hinton.   

Abstract

Oxidative stress and the accumulation of reactive oxygen species (ROS) play a role in cancer cells developing an advanced, phenotypic signature that associates with metastasis and progression. Increased ROS concentrations are involved in promoting cancer development and metastasis by inducing expression of oncogenes, suppressing activity of anti-survival molecules and by activating various cell survival and proliferation signaling pathways. Oxidative stress is higher in the epithelium of cancer patients than patients without the disease, and antioxidant trials are currently being explored as a therapeutic option. However, studies have shown that ROS increases expression of CXCR4 in cancer and immune cells. CXCR4 expression in tumors strongly correlates to metastasis and poor prognosis. Herein, we discuss an emerging relationship between ROS and CXCR4 in cancer cells.

Entities:  

Keywords:  CXCR4; ERK1/2; HIF1α; Metastasis; PI3K/AKT; Reactive oxygen species

Year:  2013        PMID： 24223583      PMCID： PMC3820291          DOI： 10.1007/s11515-012-1204-4

Source DB:  PubMed          Journal:  Front Biol (Beijing)        ISSN： 1674-7984


  55 in total

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Authors:  Karl Balabanian; Bernard Lagane; Simona Infantino; Ken Y C Chow; Julie Harriague; Barbara Moepps; Fernando Arenzana-Seisdedos; Marcus Thelen; Françoise Bachelerie
Journal:  J Biol Chem       Date:  2005-08-17       Impact factor: 5.157

2.  Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines.

Authors:  S K Gupta; P G Lysko; K Pillarisetti; E Ohlstein; J M Stadel
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3.  Reactive oxygen species regulate epidermal growth factor-induced vascular endothelial growth factor and hypoxia-inducible factor-1alpha expression through activation of AKT and P70S6K1 in human ovarian cancer cells.

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Journal:  Free Radic Biol Med       Date:  2006-08-07       Impact factor: 7.376

4.  Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury.

Authors:  K Z Guyton; Y Liu; M Gorospe; Q Xu; N J Holbrook
Journal:  J Biol Chem       Date:  1996-02-23       Impact factor: 5.157

Review 5.  Protein modification by oxidants and the role of proteolytic enzymes.

Authors:  K J Davies
Journal:  Biochem Soc Trans       Date:  1993-05       Impact factor: 5.407

Review 6.  Reactive oxygen species in cancer.

Authors:  Geou-Yarh Liou; Peter Storz
Journal:  Free Radic Res       Date:  2010-05

Review 7.  Oxidative stress, insulin signaling, and diabetes.

Authors:  Justin L Rains; Sushil K Jain
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8.  Up-regulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis.

Authors:  Hua Zhong; Gregg L Semenza; Jonathan W Simons; Angelo M De Marzo
Journal:  Cancer Detect Prev       Date:  2004

Review 9.  Reactive oxygen species: a double-edged sword in oncogenesis.

Authors:  Jin-Shui Pan; Mei-Zhu Hong; Jian-Lin Ren
Journal:  World J Gastroenterol       Date:  2009-04-14       Impact factor: 5.742

10.  Oxidative stress and its association with cardiovascular disease in chronic renal failure patients.

Authors:  Z Hambali; Z Ahmad; S Arab; H Khazaai
Journal:  Indian J Nephrol       Date:  2011-01
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  15 in total

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Authors:  Xiqian Lan; Kang Cheng; Nirupama Chandel; Rivka Lederman; Aakash Jhaveri; Mohammad Husain; Ashwani Malhotra; Pravin C Singhal
Journal:  J Leukoc Biol       Date:  2013-08-02       Impact factor: 4.962

2.  Relationship between expression of NADPH oxidase 2 and invasion and prognosis of human gastric cancer.

Authors:  Peng Wang; Qiao Shi; Wen-Hong Deng; Jia Yu; Teng Zuo; Fang-Chao Mei; Wei-Xing Wang
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3.  Cysteine (C)-X-C Receptor 4 Regulates NADPH Oxidase-2 During Oxidative Stress in Prostate Cancer Cells.

Authors:  Kia J Jones; Mahandranauth A Chetram; Danaya A Bethea; Latoya K Bryant; Valerie Odero-Marah; Cimona V Hinton
Journal:  Cancer Microenviron       Date:  2013-09-28

4.  Biodistribution of poly clustered superparamagnetic iron oxide nanoparticle labeled mesenchymal stem cells in aminoglycoside induced ototoxic mouse model.

Authors:  Ye Ji Ahn; Wan Su Yun; Jin Sil Choi; Woo Cheol Kim; Su Hoon Lee; Dong Jun Park; Jeong Eun Park; Jaehong Key; Young Joon Seo
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Review 5.  The Tumorigenic Roles of the Cellular REDOX Regulatory Systems.

Authors:  Stéphanie Anaís Castaldo; Joana Raquel Freitas; Nadine Vasconcelos Conchinha; Patrícia Alexandra Madureira
Journal:  Oxid Med Cell Longev       Date:  2015-11-22       Impact factor: 6.543

Review 6.  Oxidative Stress during HIV Infection: Mechanisms and Consequences.

Authors:  Alexander V Ivanov; Vladimir T Valuev-Elliston; Olga N Ivanova; Sergey N Kochetkov; Elizaveta S Starodubova; Birke Bartosch; Maria G Isaguliants
Journal:  Oxid Med Cell Longev       Date:  2016-10-13       Impact factor: 6.543

7.  The key role of microtubules in hypoxia preconditioning-induced nuclear translocation of HIF-1α in rat cardiomyocytes.

Authors:  Hai Guo; Hong Zheng; Jianjiang Wu; Hai-Ping Ma; Jin Yu; Maimaitili Yiliyaer
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8.  Exercise modulates redox-sensitive small GTPase activity in the brain microvasculature in a model of brain metastasis formation.

Authors:  Gretchen Wolff; Jordan E Balke; Ibolya E Andras; Minseon Park; Michal Toborek
Journal:  PLoS One       Date:  2014-05-07       Impact factor: 3.240

9.  Hedgehog inhibitors selectively target cell migration and adhesion of mantle cell lymphoma in bone marrow microenvironment.

Authors:  Han Zhang; Zheng Chen; Sattva S Neelapu; Jorge Romaguera; Nami McCarty
Journal:  Oncotarget       Date:  2016-03-22

10.  Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells.

Authors:  Natalia I Díaz-Valdivia; Claudia C Calderón; Jorge E Díaz; Lorena Lobos-González; Hugo Sepulveda; Rina J Ortíz; Samuel Martinez; Veronica Silva; Horacio J Maldonado; Patricio Silva; Sergio Wehinger; Verónica A Burzio; Vicente A Torres; Martín Montecino; Lisette Leyton; Andrew F G Quest
Journal:  Oncotarget       Date:  2017-12-05
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