Literature DB >> 2422327

Hypokinetic-rigid extrapyramidal side effects of neuroleptics: the relationship of the silent period in EMG and HVA and 5-HIAA in CSF.

O Yazici, A Hizal, L Eroğlu, A Baslo, J Yazici.   

Abstract

The relationship between cerebrospinal fluid levels of HVA and 5-HIAA and the hypokinetic-rigid symptoms that occurred during oral administration of haloperidol in twenty schizophrenic patients was investigated. Measurement of the silent period in the EMG was used for evaluation of these symptoms. The results support the hypothesis of a positive correlation between the CSF HVA and the hypokinetic-rigid side effect and a negative correlation between the pretherapeutic dopamine turnover and the risk of neuroleptic Parkinsonism.

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Year:  1986        PMID： 2422327      PMCID： PMC1028776          DOI： 10.1136/jnnp.49.4.448

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  7 in total

Review 1.  Neuroleptics as a guideline to biological research in psychotic disorders.

Authors:  H M van Praag
Journal:  Compr Psychiatry       Date:  1975 Jan-Feb       Impact factor: 3.735

2.  Clinical measurements of central dopamine and 5-hydroxytryptamine metabolism: reliability and interpretation of cerebrospinal fluid acid monoamine metabolite measures.

Authors:  M B Bowers
Journal:  Neuropharmacology       Date:  1972-01       Impact factor: 5.250

3.  Fluorimetric determination of 5-hydroxyindoleacetic acid in human urine and cerebrospinal fluid.

Authors:  J Korf; T Valkenburgh-Sikkema
Journal:  Clin Chim Acta       Date:  1969-11       Impact factor: 3.786

4.  Cerebrospinal fluid monoamine catabolites in drug-induced extrapyramidal disorders.

Authors:  T N Chase; J A Schnur; E K Gordon
Journal:  Neuropharmacology       Date:  1970-05       Impact factor: 5.250

5.  The determination of probenecid (benemid) in body fluids.

Authors:  E K TILLSON; G S SCHUCHARDT; J K FISHMAN; K H BEYER
Journal:  J Pharmacol Exp Ther       Date:  1954-08       Impact factor: 4.030

6.  Phenolic acid concentrations in the lumbar cerebrospinal fluid of Parkinsonian patients treated with L-dopa.

Authors:  I A Pullar; J M Weddell; R Ahmed; F J Gillingham
Journal:  J Neurol Neurosurg Psychiatry       Date:  1970-12       Impact factor: 10.154

7.  Levodopa in Parkinsonism: reduction in the electromyographic silent period and its relationship with tremor.

Authors:  D L McLellan
Journal:  J Neurol Neurosurg Psychiatry       Date:  1972-06       Impact factor: 10.154
  7 in total
  1 in total

1.  Extrapyramidal and depressive side reactions with flunarizine and cinarizine.

Authors:  C A Mangone; E Herskovits
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-02       Impact factor: 10.154
  1 in total

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