Literature DB >> 24222948

Interaction of IFNL3 with insulin resistance, steatosis and lipid metabolism in chronic hepatitis C virus infection.

Mohammed Eslam1, David R Booth, Jacob George, Golo Ahlenstiel.   

Abstract

Metabolic changes are inextricably linked to chronic hepatitis C (CHC). Recently polymorphisms in the IFNL3 (IL28B) region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus (HCV) infection. Further, circumstantial evidence suggests a link between IFNL3 single nucleotide polymorphisms and lipid metabolism, steatosis and insulin resistance in CHC. The emerging picture suggests that the responder genotypes of IFNL3 polymorphisms are associated with a higher serum lipid profile, and less frequent steatosis and insulin resistance. This review analyzes the current data regarding this interaction and its meaning for HCV pathogenesis and disease progression.

Entities:  

Keywords:  Chronic hepatitis C; IFNL3; Insulin resistance; Lipids

Mesh：

Substances：

Year:  2013        PMID： 24222948      PMCID： PMC3819540          DOI： 10.3748/wjg.v19.i41.7055

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  54 in total

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5.  Prevalence of liver steatosis in patients with chronic hepatitis B: a study of associated factors and of relationship with fibrosis.

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Journal:  Eur J Gastroenterol Hepatol       Date:  2006-03       Impact factor: 2.566

6.  Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.

Authors:  Dongliang Ge; Jacques Fellay; Alexander J Thompson; Jason S Simon; Kevin V Shianna; Thomas J Urban; Erin L Heinzen; Ping Qiu; Arthur H Bertelsen; Andrew J Muir; Mark Sulkowski; John G McHutchison; David B Goldstein
Journal:  Nature       Date:  2009-08-16       Impact factor: 49.962

7.  Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.

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8.  IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy.

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Journal:  Nat Genet       Date:  2009-09-13       Impact factor: 38.330

9.  IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo.

Authors:  Caroline Sommereyns; Sophie Paul; Peter Staeheli; Thomas Michiels
Journal:  PLoS Pathog       Date:  2008-03-14       Impact factor: 6.823

10.  Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.

Authors:  Stefano Romeo; Julia Kozlitina; Chao Xing; Alexander Pertsemlidis; David Cox; Len A Pennacchio; Eric Boerwinkle; Jonathan C Cohen; Helen H Hobbs
Journal:  Nat Genet       Date:  2008-09-25       Impact factor: 38.330
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Journal:  World J Diabetes       Date:  2014-10-15

2.  The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease.

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Journal:  Hepatol Int       Date:  2020-10-01       Impact factor: 6.047

3.  Interferon-λ rs12979860 genotype association with liver fibrosis in chronic hepatitis C (CHC) patients in the Pakistani population.

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4.  Polymorphisms of T helper cell cytokine-associated genes and survival of hemodialysis patients - a prospective study.

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5.  Association of IFNL3 Genotype with Hepatic Steatosis in Chronic Hepatitis C Patients Treated with Peginterferon and Ribavirin Combination Therapy.

Authors:  Shingo Nakamoto; Fumio Imazeki; Tatsuo Kanda; Shuang Wu; Masato Nakamura; Shin Yasui; Akinobu Tawada; Rintaro Mikata; Tetsuhiro Chiba; Makoto Arai; Osamu Yokosuka; Hiroshi Shirasawa
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  5 in total

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