Literature DB >> 24222925

Challenges and opportunities in synthetic biology for chemical engineers.

Yunzi Luo1, Jung-Kul Lee, Huimin Zhao.   

Abstract

Synthetic biology provides numerous great opportunities for chemical engineers in the development of new processes for large-scale production of biofuels, value-added chemicals, and protein therapeutics. However, challenges across all scales abound. In particular, the modularization and standardization of the components in a biological system, so-called biological parts, remain the biggest obstacle in synthetic biology. In this perspective, we will discuss the main challenges and opportunities in the rapidly growing synthetic biology field and the important roles that chemical engineers can play in its advancement.

Entities:  

Keywords:  Biocatalysis; Biochemical engineering; Biotechnology; Metabolic engineering; Protein engineering; Synthetic biology

Year:  2013        PMID: 24222925      PMCID: PMC3821781          DOI: 10.1016/j.ces.2012.06.013

Source DB:  PubMed          Journal:  Chem Eng Sci        ISSN: 0009-2509            Impact factor:   4.311


  44 in total

Review 1.  Bulk chemicals from biotechnology: the case of 1,3-propanediol production and the new trends.

Authors:  An-Ping Zeng; Hanno Biebl
Journal:  Adv Biochem Eng Biotechnol       Date:  2002       Impact factor: 2.635

2.  Fermentation of 10% (w/v) sugar to D: (-)-lactate by engineered Escherichia coli B.

Authors:  S Zhou; L P Yomano; K T Shanmugam; L O Ingram
Journal:  Biotechnol Lett       Date:  2005-12       Impact factor: 2.461

Review 3.  Synthetic biology for synthetic chemistry.

Authors:  Jay D Keasling
Journal:  ACS Chem Biol       Date:  2008-01-18       Impact factor: 5.100

4.  Five hard truths for synthetic biology.

Authors:  Roberta Kwok
Journal:  Nature       Date:  2010-01-21       Impact factor: 49.962

5.  Selective reduction of xylose to xylitol from a mixture of hemicellulosic sugars.

Authors:  Nikhil U Nair; Huimin Zhao
Journal:  Metab Eng       Date:  2010-05-04       Impact factor: 9.783

6.  Efficient succinic acid production from glucose through overexpression of pyruvate carboxylase in an Escherichia coli alcohol dehydrogenase and lactate dehydrogenase mutant.

Authors:  Ailen M Sánchez; George N Bennett; Ka-Yiu San
Journal:  Biotechnol Prog       Date:  2005 Mar-Apr

7.  Optimization of humanized IgGs in glycoengineered Pichia pastoris.

Authors:  Huijuan Li; Natarajan Sethuraman; Terrance A Stadheim; Dongxing Zha; Bianka Prinz; Nicole Ballew; Piotr Bobrowicz; Byung-Kwon Choi; W James Cook; Michael Cukan; Nga Rewa Houston-Cummings; Robert Davidson; Bing Gong; Stephen R Hamilton; Jack P Hoopes; Youwei Jiang; Nam Kim; Renee Mansfield; Juergen H Nett; Sandra Rios; Rendall Strawbridge; Stefan Wildt; Tillman U Gerngross
Journal:  Nat Biotechnol       Date:  2006-01-22       Impact factor: 54.908

8.  Methylglyoxal bypass identified as source of chiral contamination in l(+) and d(-)-lactate fermentations by recombinant Escherichia coli.

Authors:  T B Grabar; S Zhou; K T Shanmugam; L P Yomano; L O Ingram
Journal:  Biotechnol Lett       Date:  2006-07-26       Impact factor: 2.461

9.  Engineering of an Escherichia coli strain for the production of 3-methyl-1-butanol.

Authors:  Michael R Connor; James C Liao
Journal:  Appl Environ Microbiol       Date:  2008-08-01       Impact factor: 4.792

10.  Microbial conversion of glycerol to 1,3-propanediol by an engineered strain of Escherichia coli.

Authors:  Xueming Tang; Yongsong Tan; Hong Zhu; Kai Zhao; Wei Shen
Journal:  Appl Environ Microbiol       Date:  2009-01-09       Impact factor: 4.792

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  5 in total

Review 1.  Accelerated genome engineering through multiplexing.

Authors:  Zehua Bao; Ryan E Cobb; Huimin Zhao
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2015-09-22

2.  Development of genetic tools for the thermophilic filamentous fungus Thermoascus aurantiacus.

Authors:  Raphael Gabriel; Julia Prinz; Marina Jecmenica; Carlos Romero-Vazquez; Pallas Chou; Simon Harth; Lena Floerl; Laure Curran; Anne Oostlander; Linda Matz; Susanne Fritsche; Jennifer Gorman; Timo Schuerg; André Fleißner; Steven W Singer
Journal:  Biotechnol Biofuels       Date:  2020-10-10       Impact factor: 6.040

Review 3.  The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms.

Authors:  F Jerry Reen; Stefano Romano; Alan D W Dobson; Fergal O'Gara
Journal:  Mar Drugs       Date:  2015-07-31       Impact factor: 5.118

Review 4.  Engineering Escherichia coli to overproduce aromatic amino acids and derived compounds.

Authors:  Alberto Rodriguez; Juan A Martínez; Noemí Flores; Adelfo Escalante; Guillermo Gosset; Francisco Bolivar
Journal:  Microb Cell Fact       Date:  2014-09-09       Impact factor: 5.328

Review 5.  Synthetic Protein Scaffolds Based on Peptide Motifs and Cognate Adaptor Domains for Improving Metabolic Productivity.

Authors:  Anselm H C Horn; Heinrich Sticht
Journal:  Front Bioeng Biotechnol       Date:  2015-11-23
  5 in total

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