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Literature DB >> 2422220

Epithelial membrane antigen and cytokeratin expression by meningiomas: an immunohistological study.

J M Theaker, K C Gatter, M M Esiri, K A Fleming.

Abstract

Thirteen meningiomas of varying light microscopic features were studied immunohistologically using a panel of monoclonal antibodies directed against epithelial, mesenchymal, and neural components. All 13 meningiomas showed expression of epithelial membrane antigen, vimentin, and S100 protein, as did normal meninges. Five of the 13 meningiomas also showed focal expression of cytokeratins, with double labelling showing expression of cytokeratins and vimentin by different cells. The cytokeratin expression was especially noticeable in cells surrounding the hyaline bodies of meningiomas. These results provide further evidence that meningiomas have features of both mesenchymal and epithelial tissues.

Entities: Disease Gene

Mesh：

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Year: 1986 PMID： 2422220 PMCID： PMC499841 DOI： 10.1136/jcp.39.4.435

Source DB: PubMed Journal: J Clin Pathol ISSN： 0021-9746 Impact factor: 3.411

18 in total

1. ULTRASTRUCTURE OF MENINGIOMAS AND THE DERIVATION AND NATURE OF THEIR CELLULAR COMPONENTS.

Authors: L NAPOLITANO; R KYLE; E R FISHER
Journal: Cancer Date: 1964-02 Impact factor: 6.860

2. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

Authors: J L Cordell; B Falini; W N Erber; A K Ghosh; Z Abdulaziz; S MacDonald; K A Pulford; H Stein; D Y Mason
Journal: J Histochem Cytochem Date: 1984-02 Impact factor: 2.479

3. The use of antikeratin antibodies in the diagnosis of human neoplasms.

Authors: R B Nagle; K M McDaniel; V A Clark; C M Payne
Journal: Am J Clin Pathol Date: 1983-04 Impact factor: 2.493

Review 4. Diagnosis of pleural malignant mesothelioma in life--a practical approach.

Authors: D Whitaker; K B Shilkin
Journal: J Pathol Date: 1984-07 Impact factor: 7.996

5. Distribution of epithelial membrane antigen in normal and neoplastic tissues and it value in diagnostic tumor pathology.

Authors: J P Sloane; M G Ormerod
Journal: Cancer Date: 1981-04-01 Impact factor: 6.860

6. Prenatal diagnosis of congenital rubella.

Authors: F Daffos; F Forestier; L Grangeot-Keros; M Capella Pavlovsky; P Lebon; M Chartier; J Pillot
Journal: Lancet Date: 1984-07-07 Impact factor: 79.321

7. Cytokeratin provides a specific marker for human arachnoid cells grown in vitro.

Authors: E H Frank; B W Burge; B H Liwnicz; L J Lotspeich; J C White; S L Wechsler; F H Mayfield; J T Keller
Journal: Exp Cell Res Date: 1983-07 Impact factor: 3.905

8. Reactivity pattern of a monoclonal antikeratin antibody (KL1).

Authors: J Viac; A Reano; J Brochier; M J Staquet; J Thivolet
Journal: J Invest Dermatol Date: 1983-10 Impact factor: 8.551

9. Distribution of immunoreactive S-100 protein in pediatric brain tumors.

Authors: Y Nakamura; L E Becker; A Marks
Journal: J Neuropathol Exp Neurol Date: 1983-03 Impact factor: 3.685

Review 10. Antibodies to intermediate filament proteins in the immunohistochemical identification of human tumours: an overview.

Authors: F C Ramaekers; J J Puts; O Moesker; A Kant; A Huysmans; D Haag; P H Jap; C J Herman; G P Vooijs
Journal: Histochem J Date: 1983-07

18 in total

Review 10. Secretory meningiomas.

Authors: Nagihan Colakoğlu; Eren Demirtaş; Nezih Oktar; Nilgün Yüntem; Sertaç Islekel; Nurcan Ozdamar
Journal: J Neurooncol Date: 2003-05 Impact factor: 4.130

Epithelial membrane antigen and cytokeratin expression by meningiomas: an immunohistological study.

1. ULTRASTRUCTURE OF MENINGIOMAS AND THE DERIVATION AND NATURE OF THEIR CELLULAR COMPONENTS.

2. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

3. The use of antikeratin antibodies in the diagnosis of human neoplasms.

Review 4. Diagnosis of pleural malignant mesothelioma in life--a practical approach.

5. Distribution of epithelial membrane antigen in normal and neoplastic tissues and it value in diagnostic tumor pathology.

6. Prenatal diagnosis of congenital rubella.

7. Cytokeratin provides a specific marker for human arachnoid cells grown in vitro.

8. Reactivity pattern of a monoclonal antikeratin antibody (KL1).

9. Distribution of immunoreactive S-100 protein in pediatric brain tumors.

Review 10. Antibodies to intermediate filament proteins in the immunohistochemical identification of human tumours: an overview.

1. Primary leptomeningeal lymphoma of the cauda equina: a rare cause of radiculopathy.

2. Immunohistochemical evaluation of erbB-2 and p53 protein expression in benign and atypical human meningiomas.

3. Freiburg neuropathology case conference: a contrast-enhancing orbital, intra-conal lesion.

4. Cellular schwannoma. A clinicopathologic study of 29 cases.

Review 5. Immunohistochemistry of soft tissue tumours - review with emphasis on 10 markers.

Review 6. The application of immunohistochemistry in the diagnosis of bone tumors and tumor-like lesions.

7. Do folliculo-stellate adenomas of the pituitary gland exist or are they intrasellar meningiomas?

8. Expression of intermediate filament proteins in normal and diseased thyroid glands.

9. The p53/p21 DNA damage-signaling pathway is defective in most meningioma cells.

Review 10. Secretory meningiomas.