Literature DB >> 2422193

Lymphocyte proliferation and IgG production with herpesvirus antigens in solid phase.

P Ljungman, B Wahren, V A Sundqvist.   

Abstract

A technique for simultaneous specific lymphocyte proliferation and IgG production with herpesvirus antigens in solid phase was developed. The cell mediated immune response was highly specific. Stronger cellular responses were found after stimulation with nucleocapsid antigens than with membrane antigens. Varicella-zoster virus (VZV) and herpes simplex virus (HSV) specific antibody production in vitro were found in almost 100% of seropositive individuals, while cytomegalovirus (CMV) antibody production was detectable in 70%. A higher specific IgG production was found after stimulation with CMV and VZV membrane antigens than with CMV nucleocapsid and VZV cell antigens. No differences in IgG production were found with the two types of HSV antigens. A method for viral IgG subclass determination in vitro was also developed. These methods may be used for monitoring immunosuppressed patients for immunological responsiveness to herpesvirus infections.

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Year:  1985        PMID： 2422193     DOI： 10.1016/0166-0934(85)90130-2

Source DB:  PubMed          Journal:  J Virol Methods        ISSN： 0166-0934            Impact factor:   2.014


  9 in total

1.  Lymphocyte and IgG responses to different herpes simplex virus antigens in patients with frequent HSV-1 reactivations.

Authors:  P Ljungman; L Zetterqvist; V A Sundqvist; S Jeansson; A Heimdahl; B Wahren
Journal:  Clin Exp Immunol       Date:  1988-05       Impact factor: 4.330

2.  Monocyte and iscom enhancement of cell-mediated response to cytomegalovirus.

Authors:  B Wahren; S Nordlund; A Akesson; V A Sundqvist; B Morein
Journal:  Med Microbiol Immunol       Date:  1987       Impact factor: 3.402

3.  Mapping of IgG subclass and T-cell epitopes on HIV proteins by synthetic peptides.

Authors:  T Mathiesen; P A Broliden; J Rosen; B Wahren
Journal:  Immunology       Date:  1989-08       Impact factor: 7.397

4.  Similar humoral and cellular immunological reactivities to human herpesvirus 6 in patients with multiple sclerosis and controls.

Authors:  M Enbom; F Z Wang; S Fredrikson; C Martin; H Dahl; A Linde
Journal:  Clin Diagn Lab Immunol       Date:  1999-07

5.  Characteristics of the specific cell-mediated immune response in human immunodeficiency virus infection.

Authors:  B Wahren; L Morfeldt-Månsson; G Biberfeld; L Moberg; A Sönnerborg; P Ljungman; A Werner; R Kurth; R Gallo; D Bolognesi
Journal:  J Virol       Date:  1987-06       Impact factor: 5.103

6.  Enhancive and suppressive effects of cytomegalovirus on human lymphocyte responses in vitro.

Authors:  B Wahren; P Ljungman; T Paulin; O Ringdén
Journal:  J Virol       Date:  1986-06       Impact factor: 5.103

7.  Characterization of human monoclonal antibodies directed against the pp65-kD matrix antigen of human cytomegalovirus.

Authors:  M Ohlin; V A Sundqvist; G Gilljam; U Rudén; F O Gombert; B Wahren; C A Borrebaeck
Journal:  Clin Exp Immunol       Date:  1991-06       Impact factor: 4.330

8.  Human antibody reactivity against the lower matrix protein (pp65) produced by cytomegalovirus.

Authors:  M Ohlin; B Plachter; V A Sundqvist; P G Steenbakkers; J M Middeldorp; C A Borrebaeck
Journal:  Clin Diagn Lab Immunol       Date:  1995-05

9.  Fine specificity of the human immune response to the major neutralization epitopes expressed on cytomegalovirus gp58/116 (gB), as determined with human monoclonal antibodies.

Authors:  M Ohlin; V A Sundqvist; M Mach; B Wahren; C A Borrebaeck
Journal:  J Virol       Date:  1993-02       Impact factor: 5.103
  9 in total

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