OBJECTIVE: Results from structural neuroimaging studies of obsessive-compulsive disorder (OCD) have been only partially consistent. The authors sought to assess regional gray and white matter volume differences between large samples of OCD patients and healthy comparison subjects and their relation with demographic and clinical variables. METHOD: A multicenter voxel-based morphometry mega-analysis was performed on 1.5-T structural T1-weighted MRI scans derived from the International OCD Brain Imaging Consortium. Regional gray and white matter brain volumes were compared between 412 adult OCD patients and 368 healthy subjects. RESULTS: Relative to healthy comparison subjects, OCD patients had significantly smaller volumes of frontal gray and white matter bilaterally, including the dorsomedial prefrontal cortex, the anterior cingulate cortex, and the inferior frontal gyrus extending to the anterior insula. Patients also showed greater cerebellar gray matter volume bilaterally compared with healthy subjects. Group differences in frontal gray and white matter volume were significant after correction for multiple comparisons. Additionally, group-by-age interactions were observed in the putamen, insula, and orbitofrontal cortex (indicating relative preservation of volume in patients compared with healthy subjects with increasing age) and in the temporal cortex bilaterally (indicating a relative loss of volume in patients compared with healthy subjects with increasing age). CONCLUSIONS: These findings partially support the prevailing fronto-striatal models of OCD and offer additional insights into the neuroanatomy of the disorder that were not apparent from previous smaller studies. The group-by-age interaction effects in orbitofrontal-striatal and (para)limbic brain regions may be the result of altered neuroplasticity associated with chronic compulsive behaviors, anxiety, or compensatory processes related to cognitive dysfunction.
OBJECTIVE: Results from structural neuroimaging studies of obsessive-compulsive disorder (OCD) have been only partially consistent. The authors sought to assess regional gray and white matter volume differences between large samples of OCDpatients and healthy comparison subjects and their relation with demographic and clinical variables. METHOD: A multicenter voxel-based morphometry mega-analysis was performed on 1.5-T structural T1-weighted MRI scans derived from the International OCD Brain Imaging Consortium. Regional gray and white matter brain volumes were compared between 412 adult OCDpatients and 368 healthy subjects. RESULTS: Relative to healthy comparison subjects, OCDpatients had significantly smaller volumes of frontal gray and white matter bilaterally, including the dorsomedial prefrontal cortex, the anterior cingulate cortex, and the inferior frontal gyrus extending to the anterior insula. Patients also showed greater cerebellar gray matter volume bilaterally compared with healthy subjects. Group differences in frontal gray and white matter volume were significant after correction for multiple comparisons. Additionally, group-by-age interactions were observed in the putamen, insula, and orbitofrontal cortex (indicating relative preservation of volume in patients compared with healthy subjects with increasing age) and in the temporal cortex bilaterally (indicating a relative loss of volume in patients compared with healthy subjects with increasing age). CONCLUSIONS: These findings partially support the prevailing fronto-striatal models of OCD and offer additional insights into the neuroanatomy of the disorder that were not apparent from previous smaller studies. The group-by-age interaction effects in orbitofrontal-striatal and (para)limbic brain regions may be the result of altered neuroplasticity associated with chronic compulsive behaviors, anxiety, or compensatory processes related to cognitive dysfunction.
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Authors: Joana B Vieira; Fernando Ferreira-Santos; Pedro R Almeida; Fernando Barbosa; João Marques-Teixeira; Abigail A Marsh Journal: Soc Cogn Affect Neurosci Date: 2015-05-13 Impact factor: 3.436
Authors: Brian P Brennan; Danhong Wang; Meiling Li; Chris Perriello; Jianxun Ren; Jason A Elias; Nathaniel P Van Kirk; Jason W Krompinger; Harrison G Pope; Suzanne N Haber; Scott L Rauch; Justin T Baker; Hesheng Liu Journal: Biol Psychiatry Cogn Neurosci Neuroimaging Date: 2018-08-16
Authors: Edoardo F Q Vattimo; Vivian B Barros; Guaraci Requena; João R Sato; Daniel Fatori; Euripedes C Miguel; Roseli G Shavitt; Marcelo Q Hoexter; Marcelo C Batistuzzo Journal: Eur Child Adolesc Psychiatry Date: 2019-04-10 Impact factor: 4.785
Authors: Dan J Stein; Daniel L C Costa; Christine Lochner; Euripedes C Miguel; Y C Janardhan Reddy; Roseli G Shavitt; Odile A van den Heuvel; H Blair Simpson Journal: Nat Rev Dis Primers Date: 2019-08-01 Impact factor: 52.329
Authors: Premika S W Boedhoe; Lianne Schmaal; Yoshinari Abe; Pino Alonso; Stephanie H Ameis; Alan Anticevic; Paul D Arnold; Marcelo C Batistuzzo; Francesco Benedetti; Jan C Beucke; Irene Bollettini; Anushree Bose; Silvia Brem; Anna Calvo; Rosa Calvo; Yuqi Cheng; Kang Ik K Cho; Valentina Ciullo; Sara Dallaspezia; Damiaan Denys; Jamie D Feusner; Kate D Fitzgerald; Jean-Paul Fouche; Egill A Fridgeirsson; Patricia Gruner; Gregory L Hanna; Derrek P Hibar; Marcelo Q Hoexter; Hao Hu; Chaim Huyser; Neda Jahanshad; Anthony James; Norbert Kathmann; Christian Kaufmann; Kathrin Koch; Jun Soo Kwon; Luisa Lazaro; Christine Lochner; Rachel Marsh; Ignacio Martínez-Zalacaín; David Mataix-Cols; José M Menchón; Luciano Minuzzi; Astrid Morer; Takashi Nakamae; Tomohiro Nakao; Janardhanan C Narayanaswamy; Seiji Nishida; Erika Nurmi; Joseph O'Neill; John Piacentini; Fabrizio Piras; Federica Piras; Y C Janardhan Reddy; Tim J Reess; Yuki Sakai; Joao R Sato; H Blair Simpson; Noam Soreni; Carles Soriano-Mas; Gianfranco Spalletta; Michael C Stevens; Philip R Szeszko; David F Tolin; Guido A van Wingen; Ganesan Venkatasubramanian; Susanne Walitza; Zhen Wang; Je-Yeon Yun; Paul M Thompson; Dan J Stein; Odile A van den Heuvel Journal: Am J Psychiatry Date: 2017-12-15 Impact factor: 18.112