| Literature DB >> 24220583 |
Chunhong Gu1, Joelle Gonzalez, Tong Zhang, Suzanne Kamel-Reid, Richard A Wells.
Abstract
We observed AML cell lines vary in their sensitivity to induction of apoptosis by troglitazone (TG), which induces apoptosis through the generation of intracellular reactive oxygen species (ROS). TG-resistant cell lines had increased abundance of ARNT transcripts and protein. Expression of ARNT in TG-sensitive cells made these cells resistant to both TG and daunorubicin. ARNT-expressing cells had increased expression of SOD2 and Nrf2 transcripts and elevated intracellular GSH concentration. Our results indicate that ARNT expression in AML cells augments antioxidant response and confers resistance to ROS inducers. This suggests ARNT may modulate ROS signaling and drug response in AML.Entities:
Keywords: ARNT; Chemoresistance; Hypoxia-inducible factor; Oxidative stress; Reactive oxygen species
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Year: 2013 PMID： 24220583 DOI： 10.1016/j.leukres.2013.10.010
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156