Literature DB >> 2421847

Distribution of substance K (neurokinin A) in the brain and peripheral tissues of rats.

Y Takano, A Nagashima, H Masui, K Kuromizu, H O Kamiya.   

Abstract

The regional distribution of substance P (SP) and substance K (SK) in the central nervous system and peripheral tissues of rats was studied. High levels of SK-like immunoreactivity (SK-LI) and of SP-like immunoreactivity (SP-LI) were found in the substantia nigra, nucleus tractus solitarius and nucleus habenula. Neonatal treatment of rats with capsaicin caused a significant decrease in the SK-LI content in the submaxillary gland, but capsaicin had no effect on SK-LI content in any area of the brain. These observations suggest that SK in the brain and peripheral tissues may have significant physiological roles.

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Year:  1986        PMID： 2421847     DOI： 10.1016/0006-8993(86)90560-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  An immunohistochemical study on the innervation of SP-IR nerves in the cerebral arteries of the bent-winged bat.

Authors:  K Ando; A Ishikawa; K Kawamura; T Toda; S Arai
Journal:  Histochemistry       Date:  1989

2.  Spinal action of neurokinins producing cardiovascular responses in the conscious freely moving rat: evidence for a NK-1 receptor mechanism.

Authors:  H Hasséssian; G Drapeau; R Couture
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-12       Impact factor: 3.000

3.  Localization of neurokinin A and chromogranin A immunoreactivity in the developing porcine adrenal medulla.

Authors:  J M Wang; E F De Ridder; W P De Potter; A L Weyns
Journal:  Histochem J       Date:  1994-05

4.  Cardiovascular responses to intrathecal neuropeptide gamma in conscious rats: receptor characterization and mechanism of action.

Authors:  P Poulat; J de Champlain; R Couture
Journal:  Br J Pharmacol       Date:  1996-01       Impact factor: 8.739

5.  Tachykinin antagonists and capsaicin-induced contraction of the rat isolated urinary bladder: evidence for tachykinin-mediated cotransmission.

Authors:  C A Maggi; R Patacchini; P Santicioli; S Giuliani
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

6.  Involvement of substance P present in primary afferent neurones in modulation of cutaneous blood flow in the instep of rat hind paw.

Authors:  N Yonehara; J Q Chen; Y Imai; R Inoki
Journal:  Br J Pharmacol       Date:  1992-06       Impact factor: 8.739

7.  The intramural pelvic nerves immunoreactive for calcitonin gene-related peptide in the rectum of normal and aganglionosis rat.

Authors:  R Hirose; O Nada; T Kawana; S Suita
Journal:  Anat Embryol (Berl)       Date:  1993-01
  7 in total

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