| Literature DB >> 24218339 |
Qiang Li1, Qian Wang, Xiaoyan Xu, Songtao Ren, Li Wang.
Abstract
In order to make a comprehensive assessment of the potential association between interleukin-4 (IL-4) -589C>T and colorectal cancer (CRC) susceptibility, we conducted a meta-analysis of six epidemiological studies, which included 1,317 CRC patients and 1,659 controls. The data showed that IL-4 -589C>T was not associated with increased CRC risk in the overall population. In the subgroup analysis of IL-4 -589C>T, the results did not change when the analyses were restricted to race. Based on this meta-analysis, we conclude that IL-4 -589C>T may be not a risk factor for CRC development. Further research is needed to assess possible gene-gene or gene-environment-lifestyle interactions on CRC.Entities:
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Year: 2013 PMID： 24218339 DOI： 10.1007/s13277-013-1352-4
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283