BACKGROUND: Studies have shown that serum low-density lipoprotein (LDL-C) and non-high-density lipoprotein (non-HDL-C) have recently declined in the U.S.A. among adult and child populations despite high obesity prevalence rates. The purpose of this study was to assess whether there was a significant linear decrease in LDL-C and non-HDL-C, but not Body Mass Index (BMI) percentile among a cross-sectional, large, homogenous cohort with consistent methodology over the past decade. METHODS: A total of 47,198 children, mostly between 10 and 11 years old, participating between 2002 and 2012 were examined to assess trends in serum lipid concentration and BMI percentile. RESULTS: For LDL-C, year of screening was significant (p<0.0001) even with the inclusion of gender, age and BMI (all p<0.0001). For non-HDL-C, year of screening was also significant (p<0.0001), even with the inclusion of gender (p=0.0445), age (p<0.0001), BMI (p<0.0001) and systolic blood pressure (p=0.0021). Although some non-linear trends were also significant (e.g., a quartic trend, p<0.001), the linear trend provided the best fit for both cholesterol models. By comparison, we noted general maintenance of BMI percentile over time. CONCLUSIONS: Between 2002 and 2012, among 5th grade Appalachian children, there was a consistent linear decrease in LDL-C and non-HDL-C despite continued high prevalence rates of obesity, diabetes and hypertension. The improvement in LDL-C and non-HDL-C could be due to multifactorial causes.
BACKGROUND: Studies have shown that serum low-density lipoprotein (LDL-C) and non-high-density lipoprotein (non-HDL-C) have recently declined in the U.S.A. among adult and child populations despite high obesity prevalence rates. The purpose of this study was to assess whether there was a significant linear decrease in LDL-C and non-HDL-C, but not Body Mass Index (BMI) percentile among a cross-sectional, large, homogenous cohort with consistent methodology over the past decade. METHODS: A total of 47,198 children, mostly between 10 and 11 years old, participating between 2002 and 2012 were examined to assess trends in serum lipid concentration and BMI percentile. RESULTS: For LDL-C, year of screening was significant (p<0.0001) even with the inclusion of gender, age and BMI (all p<0.0001). For non-HDL-C, year of screening was also significant (p<0.0001), even with the inclusion of gender (p=0.0445), age (p<0.0001), BMI (p<0.0001) and systolic blood pressure (p=0.0021). Although some non-linear trends were also significant (e.g., a quartic trend, p<0.001), the linear trend provided the best fit for both cholesterol models. By comparison, we noted general maintenance of BMI percentile over time. CONCLUSIONS: Between 2002 and 2012, among 5th grade Appalachian children, there was a consistent linear decrease in LDL-C and non-HDL-C despite continued high prevalence rates of obesity, diabetes and hypertension. The improvement in LDL-C and non-HDL-C could be due to multifactorial causes.
Authors: Amy Joseph; Charles Mullett; Christa Lilly; Matthew Armistead; Harold J Cox; Michael Denney; Misha Varma; David Rich; Donald A Adjeroh; Gianfranco Doretto; William Neal; Lee A Pyles Journal: Appl Clin Inform Date: 2021-01-06 Impact factor: 2.342
Authors: Silvia Carlos; Jokin de Irala; Matt Hanley; Miguel Ángel Martínez-González Journal: J Epidemiol Community Health Date: 2014-06-24 Impact factor: 3.710