Dominique Morlet1, Geneviève Demarquay2, Frédérique Brudon3, Catherine Fischer4, Anne Caclin5. 1. INSERM, U1028, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; CNRS, UMR5292, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; Université Lyon 1, Lyon F-69000, France. Electronic address: dominique.morlet@inserm.fr. 2. Hospices Civils de Lyon, Croix-Rousse Hospital, Neurology Department, Lyon F-69000, France. 3. Tonkin Clinic, Villeurbanne F-69100, France. 4. INSERM, U1028, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; CNRS, UMR5292, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; Université Lyon 1, Lyon F-69000, France; Hospices Civils de Lyon, Neurological Hospital, Functional Neurology and Epileptology Department, Lyon F-69000, France. 5. INSERM, U1028, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; CNRS, UMR5292, Lyon Neuroscience Research Center, Brain Dynamics and Cognition Team, Lyon F-69000, France; Université Lyon 1, Lyon F-69000, France.
Abstract
OBJECTIVE: To investigate automatic event-related potentials (ERPs) to an auditory change in migraine patients. METHODS: Auditory ERPs were recorded in 22 female patients suffering from menstrually-related migraine and in 20 age-matched control subjects, in three sessions: in the middle of the menstrual cycle, before and during menses. In each session, 200 trains of tone-bursts each including two duration deviants were presented in a passive listening condition. RESULTS: In all sessions, duration deviance elicited a mismatch negativity (MMN) showing no difference between the two groups. However, migraine patients showed an increased N1 orienting component to all incoming stimuli and a prolonged N2b to deviance. They also presented a different modulation of P3a amplitude along the menstrual cycle, which tended to normalise during migraine attacks. None of the studied ERP components showed a default of habituation. CONCLUSIONS: This passive paradigm highlighted increased automatic attention orienting to auditory changes but normal auditory sensory processing in migraineurs. SIGNIFICANCE: Our observations suggest normal auditory processing up to attention triggering but enhanced activation of attention-related frontal networks in migraineurs.
OBJECTIVE: To investigate automatic event-related potentials (ERPs) to an auditory change in migrainepatients. METHODS: Auditory ERPs were recorded in 22 female patients suffering from menstrually-related migraine and in 20 age-matched control subjects, in three sessions: in the middle of the menstrual cycle, before and during menses. In each session, 200 trains of tone-bursts each including two duration deviants were presented in a passive listening condition. RESULTS: In all sessions, duration deviance elicited a mismatch negativity (MMN) showing no difference between the two groups. However, migrainepatients showed an increased N1 orienting component to all incoming stimuli and a prolonged N2b to deviance. They also presented a different modulation of P3a amplitude along the menstrual cycle, which tended to normalise during migraine attacks. None of the studied ERP components showed a default of habituation. CONCLUSIONS: This passive paradigm highlighted increased automatic attention orienting to auditory changes but normal auditory sensory processing in migraineurs. SIGNIFICANCE: Our observations suggest normal auditory processing up to attention triggering but enhanced activation of attention-related frontal networks in migraineurs.
Authors: Anthony P Kontos; Amit Reches; R J Elbin; Dalia Dickman; Ilan Laufer; Amir B Geva; Galit Shacham; Ryan DeWolf; Michael W Collins Journal: Brain Imaging Behav Date: 2016-06 Impact factor: 3.978