Literature DB >> 24216295

Monocyte-derived dendritic cells: targets as potent antigen-presenting cells for the design of vaccines against infectious diseases.

Chunfeng Qu1, Nanna-Sophie Brinck-Jensen2, Mengya Zang3, Kun Chen3.   

Abstract

Monocytes play important roles in the inflammatory response, which is essential for the innate response to pathogens. Monocytes are able to differentiate to dendritic cells (DCs) under inflammatory situations. In recent decades, the heterogeneity of monocytes and their different traffic pathways have been identified in both human and murine systems. Different monocyte subsets show distinct inflammatory cytokine profiles and differentiation potential under steady-state and inflammatory situations. We discuss the biology of monocytes, their relationship with DCs, and the potential of monocyte-derived dendritic cells (moDCs) in the design of vaccines against certain chronic infectious diseases.
Copyright © 2013 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Keywords:  Infectious diseases; Monocyte-derived dendritic cells; Monocytes; Vaccine design

Mesh：

Substances：

Year:  2013        PMID： 24216295     DOI： 10.1016/j.ijid.2013.09.023

Source DB:  PubMed          Journal:  Int J Infect Dis        ISSN： 1201-9712            Impact factor:   3.623


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