Literature DB >> 24215279

2-Methylenetetrahydropyrans: efficient partners in the carbonyl ene reaction.

Guohua Liang1, Dakin T Sharum, Troy Lam, Nancy I Totah.   

Abstract

The carbonyl ene reaction of 2-methylenetetrahydropyrans provides a rapid, high yielding route for the preparation of β-hydroxydihydropyrans under mild conditions. This process provides a new entry for the synthesis of 2-substituted tetrahydropyrans and for the direct introduction of oxygen heterocycles into molecular frameworks.

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Year:  2013        PMID： 24215279      PMCID： PMC3946575          DOI： 10.1021/ol402843s

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  11 in total

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9.  New reactions of 2-methylenetetrahydropyrans. A three component coupling protocol for the synthesis of tetrahydropyranyl ketides.

Authors:  Guohua Liang; Laura J Bateman; Nancy I Totah
Journal:  Chem Commun (Camb)       Date:  2009-09-23       Impact factor: 6.222

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