Literature DB >> 24213769

Human genetics as a foundation for innovative drug development.

Alexander Kamb1, Sean Harper, Kari Stefansson.   

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Year:  2013        PMID： 24213769     DOI： 10.1038/nbt.2732

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


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  39 in total

Review 1.  Pathologic assessment of the vulnerable human coronary plaque.

Authors:  F D Kolodgie; R Virmani; A P Burke; A Farb; D K Weber; R Kutys; A V Finn; H K Gold
Journal:  Heart       Date:  2004-12       Impact factor: 5.994

Review 2.  The value of lowering cholesterol after myocardial infarction.

Authors:  J E Rossouw; B Lewis; B M Rifkind
Journal:  N Engl J Med       Date:  1990-10-18       Impact factor: 91.245

3.  The Framingham study of coronary disease in women.

Authors:  W B Kannel; W P Castelli
Journal:  Med Times       Date:  1972-05

4.  Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9.

Authors:  Shirya Rashid; David E Curtis; Rita Garuti; Norma N Anderson; Yuriy Bashmakov; Y K Ho; Robert E Hammer; Young-Ah Moon; Jay D Horton
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-01       Impact factor: 11.205

5.  A rare variant in MYH6 is associated with high risk of sick sinus syndrome.

Authors:  Hilma Holm; Daniel F Gudbjartsson; Patrick Sulem; Gisli Masson; Hafdis Th Helgadottir; Carlo Zanon; Olafur Th Magnusson; Agnar Helgason; Jona Saemundsdottir; Arnaldur Gylfason; Hrafnhildur Stefansdottir; Solveig Gretarsdottir; Stefan E Matthiasson; Gu Mundur Thorgeirsson; Aslaug Jonasdottir; Asgeir Sigurdsson; Hreinn Stefansson; Thomas Werge; Thorunn Rafnar; Lambertus A Kiemeney; Babar Parvez; Raafia Muhammad; Dan M Roden; Dawood Darbar; Gudmar Thorleifsson; G Bragi Walters; Augustine Kong; Unnur Thorsteinsdottir; David O Arnar; Kari Stefansson
Journal:  Nat Genet       Date:  2011-03-06       Impact factor: 38.330

6.  Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.

Authors:  William E Boden; Jeffrey L Probstfield; Todd Anderson; Bernard R Chaitman; Patrice Desvignes-Nickens; Kent Koprowicz; Ruth McBride; Koon Teo; William Weintraub
Journal:  N Engl J Med       Date:  2011-11-15       Impact factor: 91.245

7.  Effects of torcetrapib in patients at high risk for coronary events.

Authors:  Philip J Barter; Mark Caulfield; Mats Eriksson; Scott M Grundy; John J P Kastelein; Michel Komajda; Jose Lopez-Sendon; Lori Mosca; Jean-Claude Tardif; David D Waters; Charles L Shear; James H Revkin; Kevin A Buhr; Marian R Fisher; Alan R Tall; Bryan Brewer
Journal:  N Engl J Med       Date:  2007-11-05       Impact factor: 91.245

8.  Mutations in PCSK9 cause autosomal dominant hypercholesterolemia.

Authors:  Marianne Abifadel; Mathilde Varret; Jean-Pierre Rabès; Delphine Allard; Khadija Ouguerram; Martine Devillers; Corinne Cruaud; Suzanne Benjannet; Louise Wickham; Danièle Erlich; Aurélie Derré; Ludovic Villéger; Michel Farnier; Isabel Beucler; Eric Bruckert; Jean Chambaz; Bernard Chanu; Jean-Michel Lecerf; Gerald Luc; Philippe Moulin; Jean Weissenbach; Annick Prat; Michel Krempf; Claudine Junien; Nabil G Seidah; Catherine Boileau
Journal:  Nat Genet       Date:  2003-06       Impact factor: 38.330

9.  Serum cholesterol as a prognostic factor after myocardial infarction: the Framingham Study.

Authors:  N D Wong; P W Wilson; W B Kannel
Journal:  Ann Intern Med       Date:  1991-11-01       Impact factor: 25.391

10.  Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis.

Authors:  Yue-Wei Qian; Robert J Schmidt; Youyan Zhang; Shaoyou Chu; Aimin Lin; He Wang; Xiliang Wang; Thomas P Beyer; William R Bensch; Weiming Li; Mariam E Ehsani; Deshun Lu; Robert J Konrad; Patrick I Eacho; David E Moller; Sotirios K Karathanasis; Guoqing Cao
Journal:  J Lipid Res       Date:  2007-04-20       Impact factor: 5.922
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  19 in total

Review 1.  Genetics of Schizophrenia: Ready to Translate?

Authors:  Claire Foley; Aiden Corvin; Shigeki Nakagome
Journal:  Curr Psychiatry Rep       Date:  2017-09       Impact factor: 5.285

Review 2.  Using human genetics to improve safety assessment of therapeutics.

Authors:  Keren J Carss; Aimee M Deaton; Alberto Del Rio-Espinola; Dorothée Diogo; Mark Fielden; Diptee A Kulkarni; Jonathan Moggs; Peter Newham; Matthew R Nelson; Frank D Sistare; Lucas D Ward; Jing Yuan
Journal:  Nat Rev Drug Discov       Date:  2022-10-19       Impact factor: 112.288

Review 3.  Drug development in the era of precision medicine.

Authors:  Sarah A Dugger; Adam Platt; David B Goldstein
Journal:  Nat Rev Drug Discov       Date:  2017-12-08       Impact factor: 84.694

4.  GWAS signals revisited using human knockouts.

Authors:  Sateesh Maddirevula; Fatema AlZahrani; Shams Anazi; Mariam Almureikhi; Tawfeg Ben-Omran; Ghada M H Abdel-Salam; Mais Hashem; Niema Ibrahim; Firdous M Abdulwahab; Neama Meriki; Fahad A Bashiri; Meow-Keong Thong; Premala Muthukumarasamy; Rifhan Azwani Mazlan; Ranad Shaheen; Fowzan S Alkuraya
Journal:  Genet Med       Date:  2017-06-22       Impact factor: 8.822

5.  Rare variant association studies: considerations, challenges and opportunities.

Authors:  Paul L Auer; Guillaume Lettre
Journal:  Genome Med       Date:  2015-02-23       Impact factor: 11.117

Review 6.  Advancing drug discovery using the power of the human genome.

Authors:  Karl Heilbron; Sahar V Mozaffari; Vladimir Vacic; Peng Yue; Wei Wang; Jingchunzi Shi; Adrian M Jubb; Steven J Pitts; Xin Wang
Journal:  J Pathol       Date:  2021-04-09       Impact factor: 7.996

Review 7.  Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects.

Authors:  Sara J Brown; Martina S Elias; Maria Bradley
Journal:  Acta Derm Venereol       Date:  2020-06-09       Impact factor: 3.875

8.  Testing the role of predicted gene knockouts in human anthropometric trait variation.

Authors:  Samuel Lessard; Alisa K Manning; Cécile Low-Kam; Paul L Auer; Ayush Giri; Mariaelisa Graff; Claudia Schurmann; Hanieh Yaghootkar; Jian'an Luan; Tonu Esko; Tugce Karaderi; Erwin P Bottinger; Yingchang Lu; Chris Carlson; Mark Caulfield; Marie-Pierre Dubé; Rebecca D Jackson; Charles Kooperberg; Barbara McKnight; Ian Mongrain; Ulrike Peters; Alex P Reiner; David Rhainds; Nona Sotoodehnia; Joel N Hirschhorn; Robert A Scott; Patricia B Munroe; Timothy M Frayling; Ruth J F Loos; Kari E North; Todd L Edwards; Jean-Claude Tardif; Cecilia M Lindgren; Guillaume Lettre
Journal:  Hum Mol Genet       Date:  2016-02-21       Impact factor: 6.150

Review 9.  Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles.

Authors:  John M Gregson; Daniel F Freitag; Praveen Surendran; Nathan O Stitziel; Rajiv Chowdhury; Stephen Burgess; Stephen Kaptoge; Pei Gao; James R Staley; Peter Willeit; Sune F Nielsen; Muriel Caslake; Stella Trompet; Linda M Polfus; Kari Kuulasmaa; Jukka Kontto; Markus Perola; Stefan Blankenberg; Giovanni Veronesi; Francesco Gianfagna; Satu Männistö; Akinori Kimura; Honghuang Lin; Dermot F Reilly; Mathias Gorski; Vladan Mijatovic; Patricia B Munroe; Georg B Ehret; Alex Thompson; Maria Uria-Nickelsen; Anders Malarstig; Abbas Dehghan; Thomas F Vogt; Taishi Sasaoka; Fumihiko Takeuchi; Norihiro Kato; Yoshiji Yamada; Frank Kee; Martina Müller-Nurasyid; Jean Ferrières; Dominique Arveiler; Philippe Amouyel; Veikko Salomaa; Eric Boerwinkle; Simon G Thompson; Ian Ford; J Wouter Jukema; Naveed Sattar; Chris J Packard; Abdulla Al Shafi Majumder; Dewan S Alam; Panos Deloukas; Heribert Schunkert; Nilesh J Samani; Sekar Kathiresan; Børge G Nordestgaard; Danish Saleheen; Joanna Mm Howson; Emanuele Di Angelantonio; Adam S Butterworth; John Danesh
Journal:  Eur J Prev Cardiol       Date:  2016-12-08       Impact factor: 7.804

10.  Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export.

Authors:  Shaun Martin; Stefanie Smolders; Peter Vangheluwe; Christine Van Broeckhoven; Chris Van den Haute; Bavo Heeman; Sarah van Veen; David Crosiers; Igor Beletchi; Aline Verstraeten; Helena Gossye; Géraldine Gelders; Philippe Pals; Norin Nabil Hamouda; Sebastiaan Engelborghs; Jean-Jacques Martin; Jan Eggermont; Peter Paul De Deyn; Patrick Cras; Veerle Baekelandt
Journal:  Acta Neuropathol       Date:  2020-03-14       Impact factor: 17.088
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