Literature DB >> 24213000

Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells.

Ryo Nakano1, Tsutomu Takahashi, Akira Naganuma, Gi-Wook Hwang.   

Abstract

HEK293 cells transfected with a double-stranded siRNA to suppress expression of the homeobox gene HOXB13 were highly resistant to oxidative stress-inducing agents, such as hydrogen peroxide, N-ethylmaleimide (NEM), and paraquat. This finding suggests that HOXB13 might enhance cell injury caused by oxidative stress.

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Year:  2013        PMID： 24213000     DOI： 10.2131/jts.38.821

Source DB:  PubMed          Journal:  J Toxicol Sci        ISSN： 0388-1350            Impact factor:   2.196


  3 in total

1.  A genome-wide DNA methylation analysis in peripheral blood from patients identifies risk loci associated with Graves' orbitopathy.

Authors:  Z Xin; L Hua; T-T Shi; X Tuo; F-Y Yang; Y Li; X Cao; J-K Yang
Journal:  J Endocrinol Invest       Date:  2017-11-30       Impact factor: 4.256

2.  The Nuclear Protein HOXB13 Enhances Methylmercury Toxicity by Inducing Oncostatin M and Promoting Its Binding to TNFR3 in Cultured Cells.

Authors:  Takashi Toyama; Sidi Xu; Ryo Nakano; Takashi Hasegawa; Naoki Endo; Tsutomu Takahashi; Jin-Yong Lee; Akira Naganuma; Gi-Wook Hwang
Journal:  Cells       Date:  2019-12-23       Impact factor: 6.600

3.  Prediction of Drug Targets for Specific Diseases Leveraging Gene Perturbation Data: A Machine Learning Approach.

Authors:  Kai Zhao; Yujia Shi; Hon-Cheong So
Journal:  Pharmaceutics       Date:  2022-01-20       Impact factor: 6.321
  3 in total

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