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Literature DB >> 2421245

A dual effect of cardiac glycosides on Ca current in single cells of frog heart.

R Fischmeister, M Brocas-Randolph, P Lechêne, J A Argibay, G Vassort.

Abstract

The effects of cardiac glycosides (1 microM ouabain, 50 microM dihydrooubain, 1 microM strophanthidin) on Ca current (ICa) were investigated on Cs-loaded single frog ventricular cells using the whole-cell patch-clamp technique (9). Cardiac glycosides exert both inhibitory and stimulatory effects on ICa in 20 Cs Ringer solution, but have only a stimulatory effect in 0 Cs, when the Na,K pump is blocked. The inhibitory response seems related to the inhibition of the Na,K pump by glycosides. The stimulatory effect on ICa may contribute to the positive inotropic effect of cardiac glycosides.

Entities: Chemical Gene

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Year: 1986 PMID： 2421245 DOI： 10.1007/bf00640925

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

18 in total

8. The time courses of the changes in contractile force and in transmembfane potentials induced by cardiac glycosides in guinea-pig papillary muscle.

Authors: H Lüllmann; U Ravens
Journal: Br J Pharmacol Date: 1973-11 Impact factor: 8.739

2. Actions of the digitalis analogue strophanthidin on action potentials and L-type calcium current in single cells isolated from the rabbit atrioventricular node.

Authors: J C Hancox; A J Levi
Journal: Br J Pharmacol Date: 1996-07 Impact factor: 8.739

3. Mechanism of action of acetylcholine on calcium current in single cells from frog ventricle.

Authors: R Fischmeister; H C Hartzell
Journal: J Physiol Date: 1986-07 Impact factor: 5.182

3 in total

A dual effect of cardiac glycosides on Ca current in single cells of frog heart.

1. The effects of sodium pump activity on the slow inward current in sheep cardiac Purkinje fibres.

2. High selectivity of calcium channels in single dialysed heart cells of the guinea-pig.

3. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

4. The toxic effects of ouabain: a voltage-clamp study.

5. Inotropic stimuli and systolic transmembrane calcium flow in depolarized guinea-pig atria.

6. Is digitalis inotropy associated with enhanced slow inward calcium current?

7. Membrane currents and tension in cat ventricular muscle treated with cardiac glycosides.

8. The time courses of the changes in contractile force and in transmembfane potentials induced by cardiac glycosides in guinea-pig papillary muscle.

9. Isolation of calcium current and its sensitivity to monovalent cations in dialysed ventricular cells of guinea-pig.

10. The relationship between sodium pump activity and twitch tension in cardiac Purkinje fibres.

1. The dual effects of ouabain on 45Ca2+ transport and contractility in adult rat ventricular myocytes.

2. Actions of the digitalis analogue strophanthidin on action potentials and L-type calcium current in single cells isolated from the rabbit atrioventricular node.

3. Mechanism of action of acetylcholine on calcium current in single cells from frog ventricle.