| Literature DB >> 24211719 |
Carole Hyacinthe1, Quentin Barraud2, François Tison3, Erwan Bezard4, Imad Ghorayeb5.
Abstract
Both excessive daytime sleepiness (EDS) and rapid eye movement (REM) sleep deregulation are part of Parkinson's disease (PD) non-motor symptoms and may complicate dopamine replacement therapy. We report here that dopamine agonists act differentially on sleep architecture in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine macaque monkey. Continuous sleep and wake electroencephalographic monitoring revealed no effect of the selective dopamine D2 receptor agonist quinpirole on EDS, whereas the selective dopamine D1 receptor agonist SKF38393 efficiently alleviated EDS and restored REM sleep to baseline values. The present results question the relevance of abandoning D1 receptor agonist treatment in PD as it might actually improve sleep-related disorders.Entities:
Keywords: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; EDS; EEG; EMG; EOG; Excessive daytime sleepiness; MPTP; Non-human primate; PD; Parkinson's disease; REM; Rapid eye movement sleep; Sleep disorders; electroencephalogram; electromyogram; electrooculogram; excessive daytime sleepiness; rapid eye movement
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Year: 2013 PMID： 24211719 DOI： 10.1016/j.nbd.2013.10.029
Source DB: PubMed Journal: Neurobiol Dis ISSN： 0969-9961 Impact factor: 5.996