Agnes Berendsen1, Aurelia Santoro2, Elisa Pini3, Elisa Cevenini4, Rita Ostan5, Barbara Pietruszka6, Katarzyna Rolf7, Noël Cano8, Aurélie Caille9, Noëlle Lyon-Belgy10, Susan Fairweather-Tait11, Edith Feskens12, Claudio Franceschi13, C P G M de Groot14. 1. Wageningen University, Department of Human Nutrition, P.O. Box 8129, 6700 EV Wageningen, The Netherlands. Electronic address: Agnes.Berendsen@wur.nl. 2. University of Bologna, Department of Experimental Diagnostic and Specialty Medicine, Via San Giacomo, 12, 40126 Bologna, Italy. Electronic address: Aurelia.santoro@unibo.it. 3. C.I.G. Interdeparmental Centre 'L. Galvani', University of Bologna, Via San Giacomo, 12, 40126 Bologna, Italy. Electronic address: Elisa.Pini5@unibo.it. 4. University of Bologna, Department of Experimental Diagnostic and Specialty Medicine, Via San Giacomo, 12, 40126 Bologna, Italy. Electronic address: Elisa.Cevenini3@unibo.it. 5. University of Bologna, Department of Experimental Diagnostic and Specialty Medicine, Via San Giacomo, 12, 40126 Bologna, Italy. Electronic address: Rita.Ostan3@unibo.it. 6. Warsaw University of Life Sciences-SGGW, Faculty of Human Nutrition and Consumer Sciences, Nowoursynowska 159c str, 02-776 Warsaw, Poland. Electronic address: Barbara_Pietruszka@sggw.pl. 7. Warsaw University of Life Sciences-SGGW, Faculty of Human Nutrition and Consumer Sciences, Nowoursynowska 159c str, 02-776 Warsaw, Poland. Electronic address: Katarzyna_Rolf@sggw.pl. 8. CHU Clermont-Ferrand, Service de Nutrition, F-63003 Clermont-Ferrand; INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France. Electronic address: noel.cano@clermont.inra.fr. 9. CHU Clermont-Ferrand, Service de Nutrition, F-63003 Clermont-Ferrand; INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France. Electronic address: aurelie.caille@clermont.inra.fr. 10. CHU Clermont-Ferrand, Service de Nutrition, F-63003 Clermont-Ferrand; INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France. Electronic address: nlyonbelgy@chu-clermontferrand.fr. 11. Norwich Medical School, Department of Nutrition, University of East Anglia, Norwich NR4 7TJ, UK. Electronic address: S.Fairweather-Tait@uea.ac.uk. 12. Wageningen University, Department of Human Nutrition, P.O. Box 8129, 6700 EV Wageningen, The Netherlands. Electronic address: Edith.Feskens@wur.nl. 13. C.I.G. Interdeparmental Centre 'L. Galvani', University of Bologna, Via San Giacomo, 12, 40126 Bologna, Italy. Electronic address: Claudio.Franceschi@unibo.it. 14. Wageningen University, Department of Human Nutrition, P.O. Box 8129, 6700 EV Wageningen, The Netherlands. Electronic address: Lisette.deGroot@wur.nl.
Abstract
BACKGROUND: The proportion of European elderly is expected to increase to 30% in 2060. Combining dietary components may modulate many processes involved in ageing. So, it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components. This paper describes the design of a healthful diet intervention on inflammageing and its consequences in the elderly. METHODS: The NU-AGE study is a parallel randomized one-year trial in 1250apparently healthy, independently living European participants aged 65-80 years. Participants are randomised into either the diet group or control group. Participants in the diet group received dietary advice aimed at meeting the nutritional requirements of the ageing population. Special attention was paid to nutrients that may be inadequate or limiting in diets of elderly, such as vitamin D, vitamin B12, and calcium. C-reactive protein is measured as primary outcome. DISCUSSION: The NU-AGE study is the first dietary intervention investigating the effect of a healthful diet providing targeted nutritional recommendations for optimal health and quality of life in apparently healthy European elderly. Results of this intervention will provide evidence on the effect of a healthful diet on the prevention of age related decline.
RCT Entities:
BACKGROUND: The proportion of European elderly is expected to increase to 30% in 2060. Combining dietary components may modulate many processes involved in ageing. So, it is likely that a healthful diet approach might have greater favourable impact on age-related decline than individual dietary components. This paper describes the design of a healthful diet intervention on inflammageing and its consequences in the elderly. METHODS: The NU-AGE study is a parallel randomized one-year trial in 1250 apparently healthy, independently living European participants aged 65-80 years. Participants are randomised into either the diet group or control group. Participants in the diet group received dietary advice aimed at meeting the nutritional requirements of the ageing population. Special attention was paid to nutrients that may be inadequate or limiting in diets of elderly, such as vitamin D, vitamin B12, and calcium. C-reactive protein is measured as primary outcome. DISCUSSION: The NU-AGE study is the first dietary intervention investigating the effect of a healthful diet providing targeted nutritional recommendations for optimal health and quality of life in apparently healthy European elderly. Results of this intervention will provide evidence on the effect of a healthful diet on the prevention of age related decline.
Authors: Pariya Behrouzi; Pol Grootswagers; Paul L C Keizer; Ellen T H C Smeets; Edith J M Feskens; Lisette C P G M de Groot; Fred A van Eeuwijk Journal: J Nutr Date: 2020-03-01 Impact factor: 4.798
Authors: Valter D Longo; Adam Antebi; Andrzej Bartke; Nir Barzilai; Holly M Brown-Borg; Calogero Caruso; Tyler J Curiel; Rafael de Cabo; Claudio Franceschi; David Gems; Donald K Ingram; Thomas E Johnson; Brian K Kennedy; Cynthia Kenyon; Samuel Klein; John J Kopchick; Guenter Lepperdinger; Frank Madeo; Mario G Mirisola; James R Mitchell; Giuseppe Passarino; Karl L Rudolph; John M Sedivy; Gerald S Shadel; David A Sinclair; Stephen R Spindler; Yousin Suh; Jan Vijg; Manlio Vinciguerra; Luigi Fontana Journal: Aging Cell Date: 2015-04-22 Impact factor: 9.304
Authors: Andrea Ticinesi; Tiziana Meschi; Fulvio Lauretani; Giovanna Felis; Fabrizio Franchi; Carlo Pedrolli; Michela Barichella; Giuseppe Benati; Sergio Di Nuzzo; Gian Paolo Ceda; Marcello Maggio Journal: Nutrients Date: 2016-03-29 Impact factor: 5.717
Authors: Lee Hooper; Asmaa Abdelhamid; Adam Ali; Diane K Bunn; Amy Jennings; W Garry John; Susan Kerry; Gregor Lindner; Carmen A Pfortmueller; Fredrik Sjöstrand; Neil P Walsh; Susan J Fairweather-Tait; John F Potter; Paul R Hunter; Lee Shepstone Journal: BMJ Open Date: 2015-10-21 Impact factor: 2.692