| Literature DB >> 24211210 |
Andra Rizqiawan1, Kei Tobiume, Gaku Okui, Kazuhiro Yamamoto, Hideo Shigeishi, Shigehiro Ono, Hiroshi Shimasue, Masaaki Takechi, Koichiro Higashikawa, Nobuyuki Kamata.
Abstract
We found that high galectin-1 (Gal-1) mRNA levels were associated with invasive squamous cell carcinoma (SCC) cells that expressed Snail, an epithelial-to-mesenchymal transition (EMT) regulator. Both Gal-1 overexpression and soluble Gal-1 treatment accelerated invasion and collective cell migration, along with activation of cdc42 and Rac. Soluble Gal-1 activated c-Jun N-terminal kinase to increase expression levels of integrins α2 and β5, which were essential for Gal-1 dependent collective cell migration and invasiveness. Soluble Gal-1 also increased the incidence of EMT in Snail-expressing SCC cells; these were a minor population with an EMT phenotype under growing conditions. Our findings indicate that soluble Gal-1 promotes invasiveness through enhancing collective cell migration and increasing the incidence of EMT.Entities:
Keywords: Collective cell migration; EMT; Galectin-1; Snail
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Year: 2013 PMID： 24211210 DOI： 10.1016/j.bbrc.2013.10.152
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575