Qingwu Wu1, Ruimin Yang, Fengmei Zhou, Ying Hu. 1. Department of Medical Imaging, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, PR China.
Abstract
PURPOSE: We performed a meta-analysis to investigate and compare diagnostic performance of whole-body MRI and skeletal scintigraphy for detection of bone metastatic tumors. MATERIALS AND METHODS: PubMed and Embase were searched for relevant articles. We calculated sensitivities, specificities, diagnostic odds ratios (DOR), positive likelihood ratios (PLR), negative likelihood ratios (NLR), and constructed summary receiver operating characteristic curves using bivariate models for whole-body MRI and skeletal scintigraphy, respectively. RESULTS: Across 7 studies (332 patients), whole-body MRI have similar patient-based sensitivity (0.84 vs 0.83), specificity (0.96 vs 0.94), DOR (137.0 vs 70.2), PLR (23.3 vs 13.0) and NLR (0.17 vs 0.19) with skeletal scintigraphy. Area under curves for whole-body MRI and skeletal scintigraphy was 0.94 and 0.89, respectively. CONCLUSION: Both whole-body MRI and skeletal scintigraphy have good diagnostic performance for detecting bone metastatic tumors. It remains inconclusive whether whole-body MRI or bone scintigraphy is superior in detecting bone metastatic tumors.
PURPOSE: We performed a meta-analysis to investigate and compare diagnostic performance of whole-body MRI and skeletal scintigraphy for detection of bone metastatic tumors. MATERIALS AND METHODS: PubMed and Embase were searched for relevant articles. We calculated sensitivities, specificities, diagnostic odds ratios (DOR), positive likelihood ratios (PLR), negative likelihood ratios (NLR), and constructed summary receiver operating characteristic curves using bivariate models for whole-body MRI and skeletal scintigraphy, respectively. RESULTS: Across 7 studies (332 patients), whole-body MRI have similar patient-based sensitivity (0.84 vs 0.83), specificity (0.96 vs 0.94), DOR (137.0 vs 70.2), PLR (23.3 vs 13.0) and NLR (0.17 vs 0.19) with skeletal scintigraphy. Area under curves for whole-body MRI and skeletal scintigraphy was 0.94 and 0.89, respectively. CONCLUSION: Both whole-body MRI and skeletal scintigraphy have good diagnostic performance for detecting bone metastatic tumors. It remains inconclusive whether whole-body MRI or bone scintigraphy is superior in detecting bone metastatic tumors.
Authors: Stuart A Taylor; Susan Mallett; Anne Miles; Stephen Morris; Laura Quinn; Caroline S Clarke; Sandy Beare; John Bridgewater; Vicky Goh; Sam Janes; Dow-Mu Koh; Alison Morton; Neal Navani; Alfred Oliver; Anwar Padhani; Shonit Punwani; Andrea Rockall; Steve Halligan Journal: Health Technol Assess Date: 2019-12 Impact factor: 4.014
Authors: Stuart A Taylor; Sue Mallett; Sandy Beare; Gauraang Bhatnagar; Dominic Blunt; Peter Boavida; John Bridgewater; Caroline S Clarke; Marian Duggan; Steve Ellis; Robert Glynne-Jones; Vicky Goh; Ashley M Groves; Ayshea Hameeduddin; Sam M Janes; Edward W Johnston; Dow-Mu Koh; Anne Miles; Stephen Morris; Alison Morton; Neal Navani; John O'Donohue; Alfred Oliver; Anwar R Padhani; Helen Pardoe; Uday Patel; Shonit Punwani; Laura Quinn; Hameed Rafiee; Krystyna Reczko; Andrea G Rockall; Khawaja Shahabuddin; Harbir S Sidhu; Jonathan Teague; Mohamed A Thaha; Matthew Train; Katherine van Ree; Sanjaya Wijeyekoon; Steve Halligan Journal: Lancet Gastroenterol Hepatol Date: 2019-05-09
Authors: Stuart A Taylor; Sue Mallett; Simon Ball; Sandy Beare; Gauraang Bhatnagar; Angshu Bhowmik; Peter Boavida; John Bridgewater; Caroline S Clarke; Marian Duggan; Steve Ellis; Robert Glynne-Jones; Vicky Goh; Ashley M Groves; Ayshea Hameeduddin; Sam M Janes; Edward W Johnston; Dow-Mu Koh; Sara Lock; Anne Miles; Stephen Morris; Alison Morton; Neal Navani; Alfred Oliver; Terry O'Shaughnessy; Anwar R Padhani; David Prezzi; Shonit Punwani; Laura Quinn; Hameed Rafiee; Krystyna Reczko; Andrea G Rockall; Peter Russell; Harbir S Sidhu; Nicola Strickland; Kathryn Tarver; Jonathan Teague; Steve Halligan Journal: Lancet Respir Med Date: 2019-05-09 Impact factor: 30.700