Literature DB >> 24210002

Urea transporter inhibitors: en route to new diuretics.

Jeff M Sands1.   

Abstract

A selective urea transporter UT-A1 inhibitor would be a novel type of diuretic, likely with less undesirable side effects than conventional diuretics, because it acts on the last portion of the nephron. In this issue of Chemistry & Biology, Esteva-Font and colleagues develop such an inhibitor by using a clever high-throughput screening assay and document its selectivity.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 24210002      PMCID： PMC3869198          DOI： 10.1016/j.chembiol.2013.10.003

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  8 in total

1.  A small molecule screen identifies selective inhibitors of urea transporter UT-A.

Authors:  Cristina Esteva-Font; Puay-Wah Phuan; Marc O Anderson; A S Verkman
Journal:  Chem Biol       Date:  2013-09-19

2.  Triazolothienopyrimidine inhibitors of urea transporter UT-B reduce urine concentration.

Authors:  Chenjuan Yao; Marc O Anderson; Jicheng Zhang; Baoxue Yang; Puay-Wah Phuan; A S Verkman
Journal:  J Am Soc Nephrol       Date:  2012-04-05       Impact factor: 10.121

3.  Nanomolar potency and metabolically stable inhibitors of kidney urea transporter UT-B.

Authors:  Marc O Anderson; Jicheng Zhang; Yan Liu; Chenjuan Yao; Puay-Wah Phuan; A S Verkman
Journal:  J Med Chem       Date:  2012-06-19       Impact factor: 7.446

4.  Vasopressin effects on urea and H2O transport in inner medullary collecting duct subsegments.

Authors:  J M Sands; H Nonoguchi; M A Knepper
Journal:  Am J Physiol       Date:  1987-11

Review 5.  Molecular mechanisms of urea transport in health and disease.

Authors:  Janet D Klein; Mitsi A Blount; Jeff M Sands
Journal:  Pflugers Arch       Date:  2012-09-25       Impact factor: 3.657

6.  Urinary concentrating defect in mice with selective deletion of phloretin-sensitive urea transporters in the renal collecting duct.

Authors:  Robert A Fenton; Chung-Lin Chou; Gavin S Stewart; Craig P Smith; Mark A Knepper
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-03       Impact factor: 11.205

Review 7.  Urea transport in the kidney.

Authors:  Janet D Klein; Mitsi A Blount; Jeff M Sands
Journal:  Compr Physiol       Date:  2011-04       Impact factor: 9.090

8.  Urea transport in MDCK cells that are stably transfected with UT-A1.

Authors:  Otto Fröhlich; Janet D Klein; Pauline M Smith; Jeff M Sands; Robert B Gunn
Journal:  Am J Physiol Cell Physiol       Date:  2004-01-28       Impact factor: 4.249
  8 in total
  9 in total

1.  Diuresis and reduced urinary osmolality in rats produced by small-molecule UT-A-selective urea transport inhibitors.

Authors:  Cristina Esteva-Font; Onur Cil; Puay-Wah Phuan; Tao Su; Sujin Lee; Marc O Anderson; A S Verkman
Journal:  FASEB J       Date:  2014-05-19       Impact factor: 5.191

2.  Phenylphthalazines as small-molecule inhibitors of urea transporter UT-B and their binding model.

Authors:  Jian-Hua Ran; Min Li; Weng-Ieong Tou; Tian-Luo Lei; Hong Zhou; Calvin Yu-Chian Chen; Bao-Xue Yang
Journal:  Acta Pharmacol Sin       Date:  2016-05-30       Impact factor: 6.150

3.  Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters.

Authors:  Huiwen Ren; Yanhua Wang; Yongning Xing; Jianhua Ran; Ming Liu; Tianluo Lei; Hong Zhou; Runtao Li; Jeff M Sands; Baoxue Yang
Journal:  Am J Physiol Renal Physiol       Date:  2014-10-08

4.  A critical analysis of urea transporter B inhibitors: molecular fingerprints, pharmacophore features for the development of next-generation diuretics.

Authors:  Sk Abdul Amin; Sudipta Nandi; Sushil Kumar Kashaw; Tarun Jha; Shovanlal Gayen
Journal:  Mol Divers       Date:  2022-01-03       Impact factor: 3.364

Review 5.  Urea transport and clinical potential of urearetics.

Authors:  Janet D Klein; Jeff M Sands
Journal:  Curr Opin Nephrol Hypertens       Date:  2016-09       Impact factor: 2.894

6.  Nanomolar-Potency 1,2,4-Triazoloquinoxaline Inhibitors of the Kidney Urea Transporter UT-A1.

Authors:  Sujin Lee; Onur Cil; Elena Diez-Cecilia; Marc O Anderson; Alan S Verkman
Journal:  J Med Chem       Date:  2018-04-03       Impact factor: 7.446

7.  Developing hypothetical inhibition mechanism of novel urea transporter B inhibitor.

Authors:  Min Li; Weng Ieong Tou; Hong Zhou; Fei Li; Huiwen Ren; Calvin Yu-Chian Chen; Baoxue Yang
Journal:  Sci Rep       Date:  2014-07-22       Impact factor: 4.379

8.  Pharmacokinetics, Tissue Distribution and Excretion of a Novel Diuretic (PU-48) in Rats.

Authors:  Zhi-Yuan Zhang; Hua Zhang; Dan Liu; Ying-Yuan Lu; Xin Wang; Pu Li; Ya-Qing Lou; Bao-Xue Yang; Ya-Xin Lou; Chuang Lu; Qiang Zhang; Guo-Liang Zhang
Journal:  Pharmaceutics       Date:  2018-08-08       Impact factor: 6.321

9.  Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.

Authors:  Galen D Reed; Cornelius von Morze; Alan S Verkman; Bertram L Koelsch; Myriam M Chaumeil; Michael Lustig; Sabrina M Ronen; Robert A Bok; Jeff M Sands; Peder E Z Larson; Zhen J Wang; Jan Henrik Ardenkjær Larsen; John Kurhanewicz; Daniel B Vigneron
Journal:  Tomography       Date:  2016-06
  9 in total

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