Literature DB >> 24209757

Responding to R-spondin: slit2 potentiates intestinal regeneration.

Toby J Phesse1, Owen J Sansom.   

Abstract

Gastrointestinal toxicity of chemoradiotherapy treatment in late-stage cancer patients limits tolerable doses and effectiveness of treatments. Zhou and colleagues in Nature (Zhou et al., 2013) suggest that activating Robo/Slit signaling in concert with R-Spondin potentiates Wnt signaling in intestinal stem cells and drives successful intestinal regeneration and recovery.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 24209757     DOI： 10.1016/j.stem.2013.10.006

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  4 in total

1.  RSPO2 enriches LGR5(+) spheroid colon cancer stem cells and promotes its metastasis by epithelial-mesenchymal transition.

Authors:  Shi Zhang; Xiaoyan Han; Bo Wei; Jiafeng Fang; Hongbo Wei
Journal:  Am J Transl Res       Date:  2016-02-15       Impact factor: 4.060

Review 2.  Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models.

Authors:  Toby J Phesse; Victoria Marsh Durban; Owen J Sansom
Journal:  Carcinogenesis       Date:  2017-10-01       Impact factor: 4.944

3.  Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.

Authors:  Dustin J Flanagan; Nick Barker; Cameron Nowell; Hans Clevers; Matthias Ernst; Toby J Phesse; Elizabeth Vincan
Journal:  Dis Model Mech       Date:  2017-06-09       Impact factor: 5.758

Review 4.  Wnt Signalling in Gastrointestinal Epithelial Stem Cells.

Authors:  Dustin J Flanagan; Chloe R Austin; Elizabeth Vincan; Toby J Phesse
Journal:  Genes (Basel)       Date:  2018-03-23       Impact factor: 4.096
  4 in total

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