| Literature DB >> 2420734 |
M Wiranowska-Stewart, J W Hadden.
Abstract
Two purine immunoenhancing drugs, isoprinosine and NPT 15392, were evaluated as inducers of IL-2 or enhancers of IL-2 induction by phytohemagglutinin (PHA). Both drugs were found to have significant enhancing activity on PHA induction of IL-2 by human lymphocytes over a wide range of concentrations. Alone they were unable to consistently induce IL-2 activity. NPT 15392 was able to enhance PHA-induced IL-2 production at 10-100 times lower concentrations than isoprinosine. The actions of these compounds to enhance IL-2 production may explain their effects on PHA-induced lymphocyte proliferation.Entities:
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Year: 1986 PMID： 2420734 DOI： 10.1016/0192-0561(86)90074-3
Source DB: PubMed Journal: Int J Immunopharmacol ISSN： 0192-0561