Benicio N Frey1, Rodrigo S Dias. 1. Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Mood Disorders Program and Women's Health Concerns Clinic, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
Abstract
OBJECTIVES: Previous studies have suggested that women with bipolar disorder are at higher risk for mood episodes during periods of intense hormonal fluctuation (e.g., premenstrual, postpartum, perimenopause). There is converging literature showing that estrogen and progesterone can modulate neurotransmitter systems and intracellular signaling pathways known to be affected by mood stabilizing agents. Here, we critically review clinical aspects of reproductive cycle events in women with bipolar disorder and preclinical studies, with a focus on the functional interactions between sex hormones and biomarkers of neuroprotection and neurodegeneration that are thought to be involved in the neurobiology of bipolar disorder: brain-derived neurotrophic factor, oxidative stress, and inflammation. METHODS: A MedLine search using estrogen, progesterone, brain-derived neurotrophic factor, oxidative stress, and inflammation as key words was conducted. RESULTS: Data showed that estrogen and progesterone closely interact with brain-derived neurotrophic factor, oxidative stress, and inflammation pathways. CONCLUSIONS: This relationship between sex hormones and the pathways of neuroprotection/neurodegeneration may be relevant to the psychopathological aspects of bipolar disorder in women.
OBJECTIVES: Previous studies have suggested that women with bipolar disorder are at higher risk for mood episodes during periods of intense hormonal fluctuation (e.g., premenstrual, postpartum, perimenopause). There is converging literature showing that estrogen and progesterone can modulate neurotransmitter systems and intracellular signaling pathways known to be affected by mood stabilizing agents. Here, we critically review clinical aspects of reproductive cycle events in women with bipolar disorder and preclinical studies, with a focus on the functional interactions between sex hormones and biomarkers of neuroprotection and neurodegeneration that are thought to be involved in the neurobiology of bipolar disorder: brain-derived neurotrophic factor, oxidative stress, and inflammation. METHODS: A MedLine search using estrogen, progesterone, brain-derived neurotrophic factor, oxidative stress, and inflammation as key words was conducted. RESULTS: Data showed that estrogen and progesterone closely interact with brain-derived neurotrophic factor, oxidative stress, and inflammation pathways. CONCLUSIONS: This relationship between sex hormones and the pathways of neuroprotection/neurodegeneration may be relevant to the psychopathological aspects of bipolar disorder in women.
Authors: Yola El Dahr; Taiane de Azevedo Cardoso; Sabrina K Syan; Luisa Caropreso; Luciano Minuzzi; Mara Smith; Olivia R Allega; Maha El-Tayebani; Jeronimo Mendes-Ribeiro; Luciano Dias de Mattos Souza; Ricardo Azevedo da Silva; Thaise Campos Mondin; Fernanda Pedrotti Moreira; Flavio Kapczinski; Karen Jansen; Benicio N Frey Journal: Arch Womens Ment Health Date: 2022-02-28 Impact factor: 3.633
Authors: Elena Aragno; Andrea Fagiolini; Alessandro Cuomo; Elena Paschetta; Giuseppe Maina; Gianluca Rosso Journal: Arch Womens Ment Health Date: 2022-03-02 Impact factor: 3.633
Authors: Armin Birner; Stephan Seiler; Nina Lackner; Susanne A Bengesser; Robert Queissner; Frederike T Fellendorf; Martina Platzer; Stefan Ropele; Christian Enzinger; Petra Schwingenschuh; Harald Mangge; Lukas Pirpamer; Hannes Deutschmann; Roger S McIntyre; Hans-Peter Kapfhammer; Bernd Reininghaus; Eva Z Reininghaus Journal: PLoS One Date: 2015-08-07 Impact factor: 3.240