OBJECTIVES: To investigate the role of LPL-Ser447Ter and Asn291Ser polymorphisms in the predisposition to different types of preeclampsia, as well as the contribution to the lipid profile and the prognosis of preeclampsia. METHODS: 125 women with preeclampsia and 131 normal pregnant women were genetically screened using PCR-restriction enzyme analysis. RESULTS: We found an increased risk for mild and severe preeclampsia in carriers of the negative Ser447/Ser447 genotype. An increased risk for severe preeclampsia in carriers of the Asn291Ser polymorphism was seen. In mild and severe preeclampsia, carriers of the negative Ser447/Ser447 genotype had increased TG and LDL-C levels and decreased HDL-C levels as compared with carriers of the Ser447Ter polymorphism. The presence of the Asn291Ser polymorphism influenced the higher TG and LDL-C levels and the lower HDL-C levels in mild preeclampsia and the higher TG and LDL-C levels in severe preeclampsia. Women with severe preeclampsia, carriers of the Ser447/Ser447 genotype and women with mild preeclampsia, carriers of the Asn291Ser polymorphism, delivered at a lower gestational age neonates with a lower birth weight compared to women carriers of this polymorphism. CONCLUSIONS: The LPL variants are associated with severe preeclampsia and influence the lipid profile and pregnancy outcome in mild and severe preeclampsia.
OBJECTIVES: To investigate the role of LPL-Ser447Ter and Asn291Ser polymorphisms in the predisposition to different types of preeclampsia, as well as the contribution to the lipid profile and the prognosis of preeclampsia. METHODS: 125 women with preeclampsia and 131 normal pregnant women were genetically screened using PCR-restriction enzyme analysis. RESULTS: We found an increased risk for mild and severe preeclampsia in carriers of the negative Ser447/Ser447 genotype. An increased risk for severe preeclampsia in carriers of the Asn291Ser polymorphism was seen. In mild and severe preeclampsia, carriers of the negative Ser447/Ser447 genotype had increased TG and LDL-C levels and decreased HDL-C levels as compared with carriers of the Ser447Ter polymorphism. The presence of the Asn291Ser polymorphism influenced the higher TG and LDL-C levels and the lower HDL-C levels in mild preeclampsia and the higher TG and LDL-C levels in severe preeclampsia. Women with severe preeclampsia, carriers of the Ser447/Ser447 genotype and women with mild preeclampsia, carriers of the Asn291Ser polymorphism, delivered at a lower gestational age neonates with a lower birth weight compared to women carriers of this polymorphism. CONCLUSIONS: The LPL variants are associated with severe preeclampsia and influence the lipid profile and pregnancy outcome in mild and severe preeclampsia.
Authors: Alejandra Abascal-Saiz; Marta Duque-Alcorta; Victoria Fioravantti; Eugenia Antolín; Eva Fuente-Luelmo; María Haro; María P Ramos-Álvarez; Germán Perdomo; José L Bartha Journal: Nutrients Date: 2022-05-23 Impact factor: 6.706
Authors: Laura Jazel Barragán-Zúñiga; Laurence A Marchat; Ivo Carrasco-Wong; Ricardo Blanco-Castaneda; José M Salas-Pacheco; Luis Ernesto Simental-Mendia; Miguel Mauricio Correa-Ramírez; Martha Sosa-Macías; Jaime Gutiérrez; Carlos Galaviz-Hernandez Journal: Front Med (Lausanne) Date: 2022-02-17
Authors: Nada Mohammed Aljuaid; Ebtesam Ibrahim Muharram; Nouf Nasser Loqtum; Reem Mohammed Al-Amoudi; Hadiah Bassam AlMahdi; Mohammed Assem Salama; Babajan Banaganapalli; Noor Ahmad Shaik; Ramu Elango; Nabeel Salem Bondagji Journal: Saudi J Med Med Sci Date: 2020-08-20