Literature DB >> 2420330

Isolation and characterization of a carcinoma-associated antigen.

A H Ross, D Herlyn, D Iliopoulos, H Koprowski.   

Abstract

GA733 is a murine IgG2a monoclonal antibody (MAb) against human gastric carcinoma and is highly tumoricidal in nude mice. The GA733 antigen is a cell surface protein with two subunits of 30,000 and 40,000 daltons. The antigen isolated by immunoaffinity chromatography consists mainly of the 30,000-dalton subunit which bears the GA733 epitope. This subunit displayed several isoelectric points between 6.9 and 7.7. Anti-colon carcinoma MAb 17-1A also detects this antigen, but probably binds to a different epitope.

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Year:  1986        PMID： 2420330     DOI： 10.1016/0006-291x(86)90976-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  20 in total

1.  Nuclear translocation of monoclonal antibody directed against cell-surface carbohydrate Y determinant.

Authors:  E M Rakowicz-Szulczynska; Z Steplewski; H Koprowski
Journal:  Am J Pathol       Date:  1992-10       Impact factor: 4.307

2.  Plant-derived anti-Lewis Y mAb exhibits biological activities for efficient immunotherapy against human cancer cells.

Authors:  Robert Brodzik; Magdalena Glogowska; Katarzyna Bandurska; Monika Okulicz; Deepali Deka; Kisung Ko; Joke van der Linden; Jeanette H W Leusen; Natalia Pogrebnyak; Maxim Golovkin; Zenon Steplewski; Hilary Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-23       Impact factor: 11.205

3.  Normal colon of Sprague-Dawley rats. An immunohistochemical study.

Authors:  J D Shetye; C A Rubio; H T Mellstedt
Journal:  Anat Embryol (Berl)       Date:  1992

4.  Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens.

Authors:  S Szala; Y Kasai; Z Steplewski; U Rodeck; H Koprowski; A J Linnenbach
Journal:  Proc Natl Acad Sci U S A       Date:  1990-09       Impact factor: 11.205

5.  Idiotypic cascades in cancer patients treated with monoclonal antibody CO17-1A.

Authors:  M Wettendorff; D Iliopoulos; M Tempero; D Kay; E DeFreitas; H Koprowski; D Herlyn
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

6.  Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733.

Authors:  A J Linnenbach; J Wojcierowski; S A Wu; J J Pyrc; A H Ross; B Dietzschold; D Speicher; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

7.  Immunohistochemical monitoring of metastatic colorectal carcinoma in patients treated with monoclonal antibodies (MAb 17-1A).

Authors:  J Shetye; J E Frödin; B Christensson; C Grant; B Jacobsson; S Sundelius; M Sylvén; P Biberfeld; H Mellstedt
Journal:  Cancer Immunol Immunother       Date:  1988       Impact factor: 6.968

8.  Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2.

Authors:  S Szala; M Froehlich; M Scollon; Y Kasai; Z Steplewski; H Koprowski; A J Linnenbach
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

9.  Regulation of protein stability by GSK3 mediated phosphorylation.

Authors:  Chong Xu; Nam-Gyun Kim; Barry M Gumbiner
Journal:  Cell Cycle       Date:  2009-12-17       Impact factor: 4.534

10.  Abnormal placental development and early embryonic lethality in EpCAM-null mice.

Authors:  Keisuke Nagao; Jianjian Zhu; Mallorie B Heneghan; Jeffrey C Hanson; Maria I Morasso; Lino Tessarollo; Susan Mackem; Mark C Udey
Journal:  PLoS One       Date:  2009-12-31       Impact factor: 3.240
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