Chuan Yang1, Huan Weng, Lihong Chen, Haiyun Yang, Guangming Luo, Lifang Mai, Guoshu Jin, Li Yan. 1. Chuan Yang, PhD, MD, Endocrinology Department, Sun Yat-sen Memorial Hospital of SunYat-sen University, Guangzhou, China. Huan Weng, MD, Endocrinology Department, Sun Yat-sen Memorial Hospital of SunYat-sen University, Guangzhou, China. Lihong Chen, PhD, MD, Endocrinology Department, Sun Yat-sen Memorial Hospital of SunYat-sen University, Guangzhou, China. Haiyun Yang, MD, Ultrasonic Department, Sun Yat-sen Memorial Hospital of SunYat-sen University, Guangzhou, China. Guangming Luo, MD, Ultrasonic Department, Sun Yat-sen Memorial Hospital of SunYat-sen University, Guangzhou, China. Lifang Mai, RN, Endocrinology Department, Sun Yat-sen Memorial Hospital of SunYat-sen University, Guangzhou, China. Guoshu Jin, MD, Endocrinology Department, Sun Yat-sen Memorial Hospital of SunYat-sen University, Guangzhou, China. Li Yan, MD, Endocrinology Department, Sun Yat-sen Memorial Hospital of SunYat-sen University, Guangzhou, China.
Abstract
PURPOSE: The purpose of this study was to investigate mean values and cut-point of transcutaneous oxygen pressure (TcPO2) measurement in patients with diabetic foot ulcers. DESIGN: Prospective, descriptive study. SUBJECTS AND SETTING: Sixty-one patients with diabetes mellitus and foot ulcers comprised the sample. The research setting was Sun Yat-sen Memorial Hospital of SunYat-sen University, Guangzhou, China. METHODS: Participants underwent transcutaneous oxygen (TcPO2) measurement at the dorsum of foot. Patients were classified into 3 groups according to clinical outcomes: (1) ulcers healed with intact skin group, (2) ulcer improved, and (3) ulcer failed to improve. TcPO2 was assessed and cut-points for predicting diabetic foot ulcer healing were calculated. RESULTS: Thirty-six patients healed with intact skin, 8 experienced improvement, and 17 showed no improvement. Mean TcPO2 levels were significantly higher (P< .001) in healed ulcers with intact skin (32 ± 10 mmHg) when compared to the improvement group (30 ± 7 mmHg) and the nonhealing group (15 ± 12 mmHg). All patients with TcPO2≤ 10 mmHg failed to heal or experienced deterioration in their foot ulcers. In contrast, all patients with TcPO2≥ 40 mmHg achieved wound closure. Measurement of TcPO2 in the supine position revealed a cut-point value of 25 mmHg as the best threshold for predicting diabetic foot ulcer healing; the area under the curve using this cut-point was 0.838 (95% confidence interval = 0.700-0.976). The sensitivity, specificity, positive predictive value, and negative predictive value for TxPO2 were 88.6%, 82.4%, 90.7%, and 72.2%, respectively. CONCLUSION: TcPO2≥ 40 mmHg was associated with diabetic foot ulcer healing, but a TcPO2≤ 10 mmHg was associated with failure of wound healing. We found that a cut-point of 25 mmHg was most predictive of diabetic foot ulcer healing.
PURPOSE: The purpose of this study was to investigate mean values and cut-point of transcutaneous oxygen pressure (TcPO2) measurement in patients with diabetic foot ulcers. DESIGN: Prospective, descriptive study. SUBJECTS AND SETTING: Sixty-one patients with diabetes mellitus and foot ulcers comprised the sample. The research setting was Sun Yat-sen Memorial Hospital of SunYat-sen University, Guangzhou, China. METHODS:Participants underwent transcutaneous oxygen (TcPO2) measurement at the dorsum of foot. Patients were classified into 3 groups according to clinical outcomes: (1) ulcers healed with intact skin group, (2) ulcer improved, and (3) ulcer failed to improve. TcPO2 was assessed and cut-points for predicting diabetic foot ulcer healing were calculated. RESULTS: Thirty-six patients healed with intact skin, 8 experienced improvement, and 17 showed no improvement. Mean TcPO2 levels were significantly higher (P< .001) in healed ulcers with intact skin (32 ± 10 mmHg) when compared to the improvement group (30 ± 7 mmHg) and the nonhealing group (15 ± 12 mmHg). All patients with TcPO2≤ 10 mmHg failed to heal or experienced deterioration in their foot ulcers. In contrast, all patients with TcPO2≥ 40 mmHg achieved wound closure. Measurement of TcPO2 in the supine position revealed a cut-point value of 25 mmHg as the best threshold for predicting diabetic foot ulcer healing; the area under the curve using this cut-point was 0.838 (95% confidence interval = 0.700-0.976). The sensitivity, specificity, positive predictive value, and negative predictive value for TxPO2 were 88.6%, 82.4%, 90.7%, and 72.2%, respectively. CONCLUSION: TcPO2≥ 40 mmHg was associated with diabetic foot ulcer healing, but a TcPO2≤ 10 mmHg was associated with failure of wound healing. We found that a cut-point of 25 mmHg was most predictive of diabetic foot ulcer healing.
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Authors: Vladimíra Fejfarová; Jiří Matuška; Edward Jude; Pavlína Piťhová; Milan Flekač; Karel Roztočil; Veronika Wosková; Michal Dubský; Alexandra Jirkovská; Robert Bém; Jitka Husáková; Věra Lánská Journal: Front Endocrinol (Lausanne) Date: 2021-12-10 Impact factor: 5.555